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Natural killer T cell strategies to combat Epstein-Barr virus infection

, : Natural killer T cell strategies to combat Epstein-Barr virus infection. Oncoimmunology 3: E28329-E28329

Epstein-Barr virus (EBV) infection results in rapid loss of CD1d expression from the surface of infected B cells, thus enabling the virus to evade immune recognition by natural killer T (NKT) cells. Using pharmacologic means to boost CD1d expression, potent NKT cell effector functions can be elicited toward EBV-infected B cells, suggesting the promise of novel strategies to target EBV-associated diseases such as some B-cell malignancies.


PMID: 25050206

DOI: 10.4161/onci.28329

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