geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Natural variation for lifespan and stress response in the nematode Caenorhabditis remanei


, : Natural variation for lifespan and stress response in the nematode Caenorhabditis remanei. Plos One 8(4): E58212-E58212

Genetic approaches (e.g. mutation, RNA interference) in model organisms, particularly the nematode Caenorhabditis elegans, have yielded a wealth of information on cellular processes that can influence lifespan. Although longevity mutants discovered in the lab are instructive of cellular physiology, lab studies might miss important genes that influence health and longevity in the wild. C. elegans has relatively low natural genetic variation and high levels of linkage disequilibrium, and thus is not optimal for studying natural variation in longevity. In contrast, its close relative C. remanei possesses very high levels of molecular genetic variation and low levels of linkage disequilibrium. To determine whether C. remanei may be a good model system for the study of natural genetic variation in aging, we evaluated levels of quantitative genetic variation for longevity and resistance to oxidative, heat and UV stress. Heritability (and the coefficient of additive genetic variation) was high for oxidative and heat stress resistance, low (but significant) for longevity, and essentially zero for UV stress response. Our results suggest that C. remanei may be a powerful system for studying natural genetic variation for longevity and oxidative and heat stress response, as well as an informative model for the study of functional relationships between longevity and stress response.

US$19.90

PMID: 23658604

DOI: 10.1371/journal.pone.0058212


Other references

White, T.; Kendi, A.Tuba.Karagulle.; Lehéricy, Séphane.; Kendi, M.; Karatekin, C.; Guimaraes, A.; Davenport, N.; Schulz, S.Charles.; Lim, K.O., 2006: Disruption of hippocampal connectivity in children and adolescents with schizophrenia--a voxel-based diffusion tensor imaging study. One hypothesis that unifies the diversity of symptoms associated with schizophrenia involves the disruption of connectivity between brain regions. As white matter provides rapid and efficient communication between brain regions, this study was ini...

Xiong, Y.; Xie, Y.; Du, G.; Su, H., 2002: From 2D framework to quasi-1D nanomaterial: preparation, characterization, and formation mechanism of Cu(3)SnS(4) nanorods. An ion-ion reaction route under solvothermal condition at relatively low temperatures was first put forward to the preparation of tetragonal Cu(3)SnS(4) nanorods, on the basis of the strategy that 2D framework structure of Cu(3)SnS(4) containing l...

Atanassoff, P.G.; Schmid, E.R.; Jenni, R.; Arbenz, U.; Alon, E.; Pasch, T., 1991: Epidural anesthesia for a cesarean section in a patient with pulmonary atresia and ventricular septal defect. The perioperative management and the pathophysiology of a parturient with pulmonary atresia, ventricular septal defect, patent ductus arteriosus Botalli (PDA), and pulmonary hypertension are described. The patient previously had a cesarean section...

Zwally H., 2004: Ice sheet mass balance from satellite altimetry. Eos, Transactions, American Geophysical Union 85(47, Suppl

Pires, M.A.Bettencourt.; Pina, M.Esperança.; Pina, J.A.Esperança., 2006: The myth of Apollo and Marsyas. Artistic representations and anatomical studies. The authors analyze an interesting sculpture found in the gardens of a 17th Century palace in Lisbon, representing the myth of Apollo and Marsyas, which led them to compare the details of the sculpture of the flayed satyr with the previous anatomi...

Terrault, N.A., 2003: Prophylactic and preemptive therapies for hepatitis C virus-infected patients undergoing liver transplantation. 1. Preclinical data from chimpanzees and studies in hepatitis B virus/hepatitis C virus (HCV) coinfected transplant recipients suggest prophylactic HCV antibody therapy may have a role in the prevention of HCV recurrence. 2. There are insufficient...

Jacobsen, J.K.S.; Haukeland, J.V., 2002: A lunch with a view: motor tourists' choices and assessments of eating-places. Utilizing data from the Norwegian Foreign Visitor Survey conducted in the summer of 1997, choices and assessments of food services among foreign motor tourists in northern Norway are investigated. Self-catering is typical for the majority of these...

McKee, L., 1998: Telephone advice scheme criticised. Bmj 317(7156): 429-429

Matthews P.B.C., 1973: The advances of the last decade of animal experimentation upon muscle spindles the background to current human work. Desmedt, John E (Ed ) New Developments in Electromyography And Clinical Neurophysiology, Vol 3 Human Reflexes, Pathophysiology Of Motor Systems And Methodology Of Human Reflexes Viii+870p Illus S Karger: Basel, Switzerland; New York, N Y , U S A 95-125

Jacobson, B.B.; Brock, K.A.; Keppler, A.B., 2000: The Post Birth Partnership: Washington State's comprehensive approach to improve follow-up care. In 1995, a group of professionals committed to providing quality maternity care in Washington State met to discuss the proposed legislation that would mandate hours of stay after delivery. The meeting resulted in the formation of the Post Birth Pa...