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Neural influence on cold induced vasodilatation using a new set-up for bilateral measurement in the rat hind limb

, : Neural influence on cold induced vasodilatation using a new set-up for bilateral measurement in the rat hind limb. Journal of Neuroscience Methods 193(1): 100-105

Cold induced vasoconstriction (CIVC) is a way for mammals to reduce heat loss in an effort to maintain body core temperature. As blood flow to a cooled extremity is reduced, the amount of body heat lost at the cooled location is minimised. However, when the extremity temperature gets below a certain threshold, Cold induced vasodilatation (CIVD) occurs, a phenomenon that is believed to reduce the risk of local cold injuries. Many theories explaining the mechanism of the CIVD reaction have been postulated, but no consensus has been found. One of these theories is that the CIVD reaction is controlled neurally. To study the effect of neural influence on the vascularisation and rewarming patterns a new experimental set-up was designed. This set-up is able to measure responses in both hind paws simultaneously, creating the opportunity to study the effect of nerve injury on one limb and use the contralateral limb as a control. Ten rats received a sciatic nerve transection and repair of either the left (n=5) or the right (n=5) hind limb. Measurements were performed, 1 day pre-operatively, directly post-operatively, and at days 1, 7, 14, 21, 35 and 49 post-operatively. Although results are not significant, there is a tendency for the CIVD reaction to be reduced in the nerve injured paw until the nerve is regenerated around day 35. Further investigation of neural influence on the CIVD reaction will be necessary; this set-up may prove to be useful in future experiments to elucidate the mechanism of the CIVD reaction.


PMID: 20709101

DOI: 10.1016/j.jneumeth.2010.08.007

Other references

Silverstone, P.H.; Attenburrow, M.J.; Robson, P., 1992: The calcium channel antagonist nifedipine causes confusion when used to treat opiate withdrawal in morphine-dependent patients. Several animal studies have suggested that calcium channel antagonists may be clinically effective in the treatment of opiate withdrawal. In this study we aimed to examine whether the alpha 2-adrenoceptor agonist clonidine and the calcium channel...

Csiky,J.; Purger,D.; Nikolic,T., 2008: Reseda inodora Rchb, a new species of the Croatian flora. A population <i>of Reseda inodora</i> Rchb. was found in Bansko brdo (Baranya, Croatia), in April 2007. This Pontic-Pannonian species was not previously included in the recent Croatian botanical database. The chorology of <i>R. i...

Mueller, P.; Rudin, D.O., 1967: Action potential phenomena in experimental bimolecular lipid membranes. Nature 213(5076): 603-604

Anonymous, 1982: Unigate has set up a new dairy in East London. The new Unigate dairy at Chadwell Heath, UK, can process 400 000 l milk/day and supplies 23 retail depots around London. Seventy-five per cent of production is in glass, with the remainder in cartons and plastics bottles, all pasteurized. Space is...

Lindzey, G.; Heinemann, S.H., 1955: Thematic apperception test: individual and group administration. Journal of Personality 24(1): 34-55

Skiba, Tm, 1973: Phyllophora as a component of mixed feeds for swine. Kombikorma v Zhivotnovodstve: 18-332

Wilhelm Helmut, 1969: Das zeitliche verhalten des erdmagnetischen quadrupolfeldes von 1835 bis 1965 (the temporal behavior of the quadrupole field from 1835 to 1965). Journal of Geophysics = Zeitschrift fuer Geophysik 35(5): 517-527

Geithe, H.P.; Asashima, M.; Born, J.; Tiedemann, H.; Tiedemann, H., 1975: Isolation of a homogeneous morphogenetic factor, inducing mesoderm and endoderm derived tissues in Triturus ectoderm. A vegetalizing factor was isolated from 12-day-old chicken embryos by isoelectric focusing and acrylamide electrophoresis. A mol. wt of 30000–32000 Daltons has been estimated for this protein by different methods.

Schiff, J.D., 1983: Least squares fit of data to hyperbolic dose-response curves using a programmed minicalculator (TI-59). Equations of the Michaelis-Menten form are frequently encountered in a number of areas of biochemical and pharmacological research. A program is presented for use on the programmable TI-59 calculator with added printer which performs an iterative...

Holle, I.S., 1953: A case of incurable peptic ulcer. Medical Journal of Australia 2(15): 567-568