+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Neurobehavioral mechanisms of temporal processing deficits in Parkinson's disease

, : Neurobehavioral mechanisms of temporal processing deficits in Parkinson's disease. Plos One 6(2): E17461-E17461

Parkinson's disease (PD) disrupts temporal processing, but the neuronal sources of deficits and their response to dopamine (DA) therapy are not understood. Though the striatum and DA transmission are thought to be essential for timekeeping, potential working memory (WM) and executive problems could also disrupt timing. The present study addressed these issues by testing controls and PD volunteers 'on' and 'off' DA therapy as they underwent fMRI while performing a time-perception task. To distinguish systems associated with abnormalities in temporal and non-temporal processes, we separated brain activity during encoding and decision-making phases of a trial. Whereas both phases involved timekeeping, the encoding and decision phases emphasized WM and executive processes, respectively. The methods enabled exploration of both the amplitude and temporal dynamics of neural activity. First, we found that time-perception deficits were associated with striatal, cortical, and cerebellar dysfunction. Unlike studies of timed movement, our results could not be attributed to traditional roles of the striatum and cerebellum in movement. Second, for the first time we identified temporal and non-temporal sources of impaired time perception. Striatal dysfunction was found during both phases consistent with its role in timekeeping. Activation was also abnormal in a WM network (middle-frontal and parietal cortex, lateral cerebellum) during encoding and a network that modulates executive and memory functions (parahippocampus, posterior cingulate) during decision making. Third, hypoactivation typified neuronal dysfunction in PD, but was sometimes characterized by abnormal temporal dynamics (e.g., lagged, prolonged) that were not due to longer response times. Finally, DA therapy did not alleviate timing deficits. Our findings indicate that impaired timing in PD arises from nigrostriatal and mesocortical dysfunction in systems that mediate temporal and non-temporal control-processes. However, time perception impairments were not improved by DA treatment, likely due to inadequate restoration of neuronal activity and perhaps corticostriatal effective-connectivity.


PMID: 21364772

DOI: 10.1371/journal.pone.0017461

Other references

Pedersen, Am, 1984: The forestry school. Tidsskrift Dansk skovforening 69(1): 161-173

Vertongen F.; Heyder Bruckner C.; Fondu P.; Mandelbaum I., 1981: Oxidative hemolysis in protein mal nutrition. A study of the hemolytic anemia observed in protein-energy malnutrition (PEM) in Kivu, Zaire, disclosed the following results. The in vitro resistance to oxidative aggressions of PEM patients' erythrocytes was decreased; when incubated with a...

Brown, A.N.; Zakharov, L.N.; Mikulas, T.; Dixon, D.A.; Liu, S-Yuan., 2014: Rhodium-catalyzed B-H activation of 1,2-azaborines: synthesis and characterization of BN isosteres of stilbenes. The first example of catalytic B-H activation of azaborines leading to a new family of stilbene derivatives through dehydrogenative borylation is reported. Ten 1,2-azaborine-based BN isosteres of stilbenes have been synthesized using this method,...

Mchedlidze, G.A., 1964: Some questions of biology and evolution of the cetaceans. Doklady Sov Paleont Prob, 8: 37-46

Walbrecq, G.; Wang, B.; Becker, S.; Hannotiau, A.; Fransen, M.; Knoops, B., 2016: Antioxidant cytoprotection by peroxisomal peroxiredoxin-5. Peroxiredoxin-5 (PRDX5) is a thioredoxin peroxidase that reduces hydrogen peroxide, alkyl hydroperoxides, and peroxynitrite. This enzyme is present in the cytosol, mitochondria, peroxisomes, and nucleus in human cells. Antioxidant cytoprotective f...

Church, H.N.; Clayton, M.M.; Young, C.M.; Foster, W.D., 1954: Can different interviewers obtain comparable dietary survey data?. Journal of the American Dietetic Association 30(8): 777-779

Makubi, A.; Hage, C.; Lwakatare, J.; Kisenge, P.; Makani, J.; Rydén, L.; Lund, L.H., 2014: Contemporary aetiology, clinical characteristics and prognosis of adults with heart failure observed in a tertiary hospital in Tanzania: the prospective Tanzania Heart Failure (TaHeF) study. This study aimed to describe the contemporary aetiology, clinical characteristics and mortality and its predictors in heart failure (HF) in Tanzania. Design; Prospective observational study. Setting; Cardiovascular Center of the Muhimbili National...

Pontes, D.Guedes.; Correa, K.Michele.; Cohen-Carneiro, Fávia., 2012: Re-establishing esthetics of fluorosis-stained teeth using enamel microabrasion and dental bleaching techniques. Dental fluorosis manifests itself as white stains on the enamel of teeth exposed to excessive doses of fluoride during their formation. Fluorosis usually occurs as a result of the ingestion of dentifrices, gels and fluoridated solutions. It may be...

Korngold, L.; Va.L.Euwen, G.; Miller, D.G., 1961: The antigens of human leukocytes. II. The specificity of leukocyte antigens. Journal of the National Cancer Institute 26: 557-567

Pensgaard, A.M.; Roberts, G.C., 2002: Elite athletes' experiences of the motivational climate: The coach matters. Recent research investigating the effect of the motivational climate has found that even elite athletes benefit from a mastery climate. The purpose of the present study was to obtain a deeper understanding of the importance of the climate surround...