+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Neurophysiological determinants of tic severity in children with chronic motor tic disorder

, : Neurophysiological determinants of tic severity in children with chronic motor tic disorder. Applied Psychophysiology and Biofeedback 36(2): 121-127

Tics wax and wane in severity. Although the understanding of the natural course of symptoms in tic disorder (TD) is important for planning and assessing therapeutic interventions, neurophysiological mechanisms and predictors of tic exacerbation and remission have not been sufficiently investigated. In each of seven children suffering from TD, contingent negative variation (CNV) was recorded on 10 occasions over a period of 2 months. CNV parameters of children with TD were compared with CNV data of healthy, age-matched children. During the entire time of observation, tic severity was assessed by parents and the investigator using a scale developed from the Yale Global Tic Severity Scale. Moreover, tic severity was also evaluated using video assessments. Patients with TD were characterized by significantly lower amplitude of the total CNV and more pronounced habituation of the early CNV component as compared to healthy children. Correlation analysis between tic severity and CNV parameters demonstrated that the more severe the tics were, the lower the amplitude of the total CNV. Since CNV amplitude represents processes of resource mobilization and control over neuronal excitability, tic severity may result from less ability to control neurophysiological functions in patients with TD.


PMID: 21431421

DOI: 10.1007/s10484-011-9155-0

Other references

Clark, Gordon M., 1956: The effects of infrared radiation on the Ehrlich ascites tumor. Total body radiation (10,000 A) was given continuously for a 24-day period. Mitotic indices were determined daily for treated and control groups. Growth and survival curves were determined from data collected at three-day intervals for 45 days. Co...

Balakathiresan, N.; Bhomia, M.; Chandran, R.; Chavko, M.; McCarron, R.M.; Maheshwari, R.K., 2013: MicroRNA let-7i is a promising serum biomarker for blast-induced traumatic brain injury. Blast-induced traumatic brain injury (TBI) is of significant concern in soldiers returning from the current conflicts in Iraq and Afghanistan. Incidents of TBI have increased significantly in the current conflicts compared to previous wars, and a...

Vogler L.B.; Anderson S.J.; Kinney M.C., 1987: Transforming growth factor type beta tgf beta inhibits the growth and differentiation of normal but not transformed b lymphocytes. Pediatric Research 21(4 PART 2): 319A

Banerjee Dipanjan; Nelson Hanna; Persson Per, 2007: EXAFS and XPS study of arsenate adsorption on manganite (gamma -MnOOH) surfaces. Geochimica et Cosmochimica Acta 71(15S): A58

Heilbronn, Edith, 1963: Studies on the interaction between oximes and organo-phosphorus compounds or phosphorylated cholinesterases. Acta Chem Scand: 876

Smirnov, I.; Tereshchenko, I., 1976: The optimum time for inseminating pigs. Data were obtained on 752 Russian Large White sows and 367 replacement gilts. The majority of females exhibited oestrus between 18.00 and 03.00 h, the percentage being 75.7 and 72.1 for the 2 groups resp. in Dec. and 77.2 and 67.9 in July. For sow...

Stevenson, C.G.; Beane, W.Scott., 2011: A low percent ethanol method for immobilizing planarians. Planarians have recently become a popular model system for the study of adult stem cells, regeneration and polarity. The system is attractive for both undergraduate and graduate research labs, since planarian colonies are low cost and easy to main...

Dowd, J.B.; Palermo, T.; Chyu, L.; Adam, E.; McDade, T.W., 2014: Re: Childhood adversity and cell-mediated immunity in young adulthood. Brain, Behavior, and Immunity 34: 176-176

Amlerová, J.; Studentová, V.; Hrabák, J., 2015: Identification of Mycobacterium spp. isolates using matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF MS). Matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF MS) has recently been widely used in diagnostic microbiological laboratories. It is a cheap and rapid method for the identification of bacteria and micromycete...

Abstracts., 1978: Abstracts of papers of the 50th annual meeting of the Genetics Society of Japan. Japanese Journal of Genetics, 536: 411-470