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New genetic links in eosinophilic esophagitis


, : New genetic links in eosinophilic esophagitis. Genome Medicine 2(9): 60-60

Eosinophilic esophagitis (EoE) is increasingly diagnosed as a disorder throughout the world. It is characterized by eosinophils in the esophagus due to food allergies. Molecular analysis of esophageal biopsies and mouse models have indicated a clear role for the T helper 2 pathway, in particular interleukins 5 and 13, in this disease. Current treatment options for EoE involve avoidance of the allergens or using anti-inflammatory medications such as topical corticosteroids. In the past year, genomic research has led to the identification of single nucleotide polymorphisms in the gene encoding thymic stromal lymphopoietin (TSLP), and subsequently in the gene encoding its receptor, as disease susceptibility markers for EoE. Identification of this molecule and its receptor suggest the potential for new treatment options in the future.

US$19.90

PMID: 20822553

DOI: 10.1186/gm181


Other references

Chen Y D., 1983: On the transport noise of hydrophobic ions in lipid bi layer membranes. The effect of transit time on the electrical transport noise of a closed 1-barrier model at equilibrium as proposed by Kolb and Lauger is studied using the master-equation approach. A transit time is the time for an ion to cross the energy barrier...

Fleming H.W.W., 1957: Magnetic and electromagnetic investigations in Paska township, District of Thunder Bay, Ontario. The results of an exploration program organized to investigate some large aeromagnetic anomalies which indicated large extensions to the known Onaman Fe range, are discussed and compared with the predictions made from the interpretation of the mag...

Taylor H., 1967: New drugs actions and applications. Pharmaceutical Journal of New Zealand 29(12): 13

Ismay J.W., 1990: A new aragara walker diptera chloropidae from malaysia. Entomologist's Monthly Magazine 126(1516-1519): 217-221

Zimmerman, R.L.; Montone, K.T.; Fogt, F.; Norris, A.H., 2000: Ultra fast identification of Aspergillus species in pulmonary cytology specimens by in situ hybridization. The cytologic diagnosis of pulmonary aspergillosis infection is typically made on a presumptive basis and later confirmed by fungal culture, which may take up to one week to complete. An in situ hybridization (ISH) probe specific for Aspergillus f...

Nozawa, H.; Watanabe, T.; Ohnishi, T.; Tada, T.; Tsurita, G.; Sasaki, S.; Kitayama, J.; Nagawa, H., 2003: Detection of cancer cells in mesenteric vein and peripheral vessels by measuring telomerase activity in patients with colorectal cancer. Background. Liver metastasis is an important factor determining prognosis in colorectal cancer. The objective of this study was to assess whether colorectal cancer cells in the drainage veins can be detected by measuring telomerase activity and it...

Barros, J., 1942: Ox warbles. This is a review of present knowledge of Hypoderma infestation which is apparently common in Portugal. B. calls for urgent control measures.

Della Lucia, R.M.; Vital, B.R., 1989: Adhesion tests on Eucalyptus gummifera, E. paniculata and E. resinifera wood. Animal protein-based glue, urea formaldehyde, resorcinol formaldehyde or polyvinyl acetate were used to glue joints in Eucalyptus gummifera, E. paniculata or E. resinifera wood. For each species, 50% of the joints were made using wood washed with...

Rukhkyan A.A., 1985: New armenian breed of semicoarse wooled sheep. Biologicheskii Zhurnal Armenii 38(4): 279-283

Lung, J.; Pedersen, H.E.; Olsen, P.Z.; Hvidberg, E.F., 1971: Early human studies of a new carbonic anhydrase inhibitor (NSD 3004) with anticonvulsant properties. Clinical Pharmacology and Therapeutics 12(6): 902-912