geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

New therapeutic approaches in glioblastomas


, : New therapeutic approaches in glioblastomas. Revue Neurologique 164(6-7): 554-559

Current treatment of glioblastomas relies on surgical resection, radiotherapy and chemotherapy. However, the efficacy of these therapeutics is still limited and new therapeutic approaches based on the understanding of brain tumor biology are emerging. High expression of the EGF receptor by tumor cells, activation of the PI3K/Akt and the Ras/Raf pathways represent interesting targets for new selective drugs under development. The most promising drugs are currently antiangiogenic agents. This article reviews these emerging therapies currently under clinical trials in glioblastomas.

US$19.90

PMID: 18565354

DOI: 10.1016/j.neurol.2008.03.017


Other references

Hirsch, E.F.; Meyer, K.A., 1972: Karl A. Meyer 1886-1972. Proceedings of the Institute of Medicine of Chicago 29(1): 24-24

Kvitsand, Hanne M.L., 2008: Pathogens in the subsurface; mobility and attenuation. NGU Rapport: 19-20

Davydov, S.N.; Aleshker, V.T.; BlokM.Y., 1967: Experience in the use of radiotelemetry for the study of the functional condition of the female sexual system. Data obtained from this experiment indicate that the radiotelemetric device "Kapsul" developed by A. M. Sorin can be used for examinations in an obstetrical-gynecological clinic.

Kobayashi, N.; Taniguchi, K.; Urasawa, T.; Urasawa, S., 1995: Preferential selection of specific rotavirus gene segments in coinfection and multiple passages with reassortant viruses and their parental strain. We previously reported non-random selections of human rotavirus (HRV) Wa genes 2 and 5 in reassortant formation between HRV strains Wa and HN126 under selection pressure with neutralizing monoclonal antibodies. In order to study whether or not the...

Shubladze, A.K., 1954: Experimental production of Botkin's epidemic hepatitis. Zhurnal Mikrobiologii, Epidemiologii, i Immunobiologii 7: 38-43

Sturrock, R.F., 1965: The Development Of Irrigation And Its Influence On The Transmission Of Bilharziasis In Tanganyika. Schistosoma mansoni and Schistosoma haematobium are widely distributed throughout East Africa, each being transmitted by several intermediate hosts. It is feared that the increased use of irrigation, which is proposed in Tanganyika to expand agric...

Santiago-Mejia, J.; Ventura-Martinez, R.; Gomez, C.; Parra-Gamez, L.; Gonzales-Rios, J.; Rodriguez, R., 2007: Polyviewed expression of the altered contractility of the guinea-pig ileum after ischemia in situ and superfusion in vitro. This study deals with the polyviewed expression of the altered contractility of the isolated ileum of the guinea-pig after ischemia/superfusion (I/S). Intestinal ischemia was produced by clamping the superior mesenteric artery for 40, 80 or 160 m...

Pulido Bosch Antonio; Ben Sbih Younes, 1993: The Careos, a traditional system for artificial recharge in the southern Sierra Nevada (Granada, Spain). Memoires - Association Internationale des Hydrogeologues = Memoires - International Association of Hydrogeologists 24: 301-310

Arakawa, Kiichi, 1966: A total chemical synthesis of crystalline bovine insulin On the results performed by the chemists in the People s Republic of China. This paper describes the total chemical synthesis of crystalline bovine insulin performed by the chemists in the People's Republic of China. The major items are as follows: (1) Introductory remarks. (2) Resynthesis of insulin from its A and B...

Liebl, N.A.; Butler, L.M., 1990: A chiropractic approach to the treatment of dysmenorrhea. This time-series case study was designed to determine whether manipulating the spine can be an effective method of relief from dysmenorrhea. A patient suffering from dysmenorrhea monitored her monthly menstrual cramps by using pain diaries. She ra...