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Newborns' cord blood plasma cotinine concentrations are similar to that of their delivering smoking mothers


, : Newborns' cord blood plasma cotinine concentrations are similar to that of their delivering smoking mothers. Drug and Alcohol Dependence 107(2-3): 250-252

In utero exposure to constituents of tobacco smoke has perinatal and postnatal health consequences. Umbilical cord plasma cotinine levels have been shown to correlate with self-reported daily number of cigarettes at the end of pregnancy, but the exact relationship between maternal and newborn plasma cotinine (and nicotine) is unknown. Concentrations of cotinine, nicotine's main metabolite, were determined in venous blood of delivering mothers and in arterial umbilical cord blood of their newborns at birth. Data from eighteen mother-newborn dyads were analyzed. The mothers smoked 95.1 (SD=96, range 10-420) cigarettes the week preceding delivery. Their mean plasma cotinine concentration at delivery was 106 ng/mL (SD=53, range 17-245) and the newborns' mean umbilical cord plasma cotinine was 88.2 ng/mL (SD=53, range 10-198, p<0.001). The difference can be explained by the elimination time of around 6h which occurred between sampling in mothers and in umbilical cord blood. Arterial umbilical cord blood plasma cotinine was highly associated with that of the smoking mothers: y=0.79x+0.97, Rsq=0.95, p<0.001. Maternal and newborn plasma cotinine concentrations are strongly associated. There is probably no placental barrier for plasma cotinine between pregnant mothers and their newborns. Lack of a placental barrier for cotinine (and probably nicotine) can partially explain smoking related perinatal disorders.

US$19.90

PMID: 19939584

DOI: 10.1016/j.drugalcdep.2009.10.008


Other references

Headings, V.E.; Anyaibe, S.I.O.; Bhattacharya, S.P.; Hopkins, E.L., 1978: Early diagnosis of hemo globinopathies. Antibodies specific for human Hbs F, A, S and C were isolated by affinity chromatography from antisera produced in rabbits and goats. These reagents possessed adequate sensitivity for identifying and quantifying Hb A, S and C in cord blood by radi...

Gammon, M.D.; Eng, S.M.; Teitelbaum, S.L.; Britton, J.A.; Kabat, G.C.; Hatch, M.; Paykin, A.B.; Neugut, A.I.; Santella, R.M., 2004: Environmental tobacco smoke and breast cancer incidence. To evaluate whether environmental tobacco smoke (ETS) influences breast cancer incidence, data from a population-based case-control study were analysed. Respondents with available ETS information assessed by in-person questionnaires included 1356...

Henninges J.; Schroetter J.; Erbas K.; Huenges E., 2002: Temperature profiles during a gas hydrate production test. Geotechnologien (Potsdam) 1: 53-55

Saunders, E.D., 1982: Sport and culture: elitism or pluralism?. Students of cultural activities have noted the continuing existence of two kinds of culture, which have become known as high and popular culture. Advocates of high culture have failed to consider the significance of sport in society, relegating it...

O'Neill, G.; Owen, W.A., 1987: Computerized analysis of the caloric response. Caloric responses from 50 consecutive patients, referred routinely for investigation of hearing and/or balance problems, were evaluated by computer and manual methods of analysis. Using measures of nystagmic slow-phase velocity, there was found to...

Lagana, A.; Vadnais, J.; Le, P.U.; Nguyen, T.N.; Laprade, R.; Nabi, I.R.; Noël, J., 2000: Regulation of the formation of tumor cell pseudopodia by the Na(+)/H(+) exchanger NHE1. The Na(+)/H(+) exchanger NHE1 is involved in intracellular pH homeostasis and cell volume regulation and accumulates with actin in the lamellipodia of fibroblasts. In order to determine the role of NHE1 following epithelial transformation and the...

Hermosilla, JG., 1972: Variacion estacional de los dinoflagelados y tintinidos en la Bahia de Concepcion, Chile. Boletin Soc Biol Concepcion, 44: 149-160

Morita, H.; Tahara, T.; Matsumoto, A.; Kato, T.; Miyazaki, H.; Ohashi, H., 1996: Functional analysis of the cytoplasmic domain of the human Mpl receptor for tyrosine-phosphorylation of the signaling molecules, proliferation and differentiation. To investigate the functional domains for signal transduction of human Mpl, we constructed a series of human c-mpl cDNAs with various deletions in the cytoplasmic domain, and then introduced each cDNA into murine IL-3-dependent myeloid leukemia FD...

Cao, X.; Zhang, L.; Wang, L.; Lin, J., 2014: Insights into ordered microstructures and ordering mechanisms of ABC star terpolymers by integrating dynamic self-consistent field theory and variable cell shape methods. A theoretical approach coupling dynamic self-consistent field (SCF) theory for inhomogeneous polymeric fluids and variable cell shape (VCS) method for automatically adjusting cell shape and size is developed to investigate ordered microstructures...

Quint, L., 1987: The truth about prepared pizzas. A brief report discusses the nutritional limitations posed by prepared pizzas and provides guidelines for improving their nutritional value. Specifically, the fat, salt, and additive contents of prepared pizzas are discussed. Levels of salt and of...