geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Nitrite reduction and cardiovascular protection


, : Nitrite reduction and cardiovascular protection. Journal of Molecular and Cellular Cardiology 73: 57-69

Inorganic nitrite, a metabolite of endogenously produced nitric oxide (NO) from NO synthases (NOS), provides the largest endocrine source of directly bioavailable NO. The conversion of nitrite to NO occurs mainly through enzymatic reduction, mediated by a range of proteins, including haem-globins, molybdo-flavoproteins, mitochondrial proteins, cytochrome P450 enzymes, and NOS. Such nitrite reduction is particularly favoured under hypoxia, when endogenous formation of NO from NOS is impaired. Under normoxic conditions, the majority of these nitrite reductases also scavenge NO, or diminish its bioavailability via reactive oxygen species (ROS) production, suggesting an intricate balance. Moreover, nitrite, whether produced endogenously, or derived from exogenous nitrite or nitrate administration (including dietary sources via the Nitrate-Nitrite-NO pathway) beneficially modulates many key cardiovascular pathological processes. In this review, we highlight the landmark studies which revealed nitrite's function in biological systems, and inspect its evolving role in cardiovascular protection. Whilst these effects have mainly been ascribed to the activity of one or more nitrite reductases, we also discuss newly-identified mechanisms, including nitrite anhydration, the involvement of s-nitrosothiols, nitro-fatty acids, and direct nitrite normoxic signalling, involving modification of mitochondrial structure and function, and ROS production. This article is part of a Special Issue entitled "Redox Signalling in the Cardiovascular System".

US$19.90

PMID: 24486197

DOI: 10.1016/j.yjmcc.2014.01.012


Other references

Reynaud, A.; Barthélemy, F.V.; Masson, G.S.; Chavane, F., 2007: Input-output transformation in the visuo-oculomotor loop: comparison of real-time optical imaging recordings in V1 to ocular following responses upon center-surround stimulation. In psychophysics and physiology, it is well established that lateral interactions are crucial mechanisms to constrain response normalization and contextual modulations. To study the cortical mechanisms involved in the contextual modulation of the...

Peng, Q., 1992: Effects of prostaglandin E2 on growth and function of osteoblasts in human cell culture in vitro. The effects of prostaglandin E 2 (PGE2) on the differentiation and proliferation of osteoblasts (human fetal bone-cells) cultured in serum-free medium were investigated by assays of alkaline phosphatase (ALP) activity, intracellular cyclic AMP lev...

Nishio J.; Whitmarsh J., 1988: Effect of uncouplers on membrane potential in intact chloroplasts consequences for membrane transport studies. Plant Physiology (Rockville) 86(4 SUPPL): 86

Furuhata, T.; Kaise, M.; Hoteya, S.; Iizuka, T.; Yamada, A.; Nomura, K.; Kuribayashi, Y.; Kikuchi, D.; Matsui, A.; Ogawa, O.; Yamashta, S.; Mitani, T., 2016: Postoperative bleeding after gastric endoscopic submucosal dissection in patients receiving antithrombotic therapy. It is controversial whether antithrombotic therapy increases the risk of bleeding after endoscopic submucosal dissection (ESD). The aim of this study was to evaluate the effects of antithrombotic therapy on gastric ESD. Patients who underwent gast...

Chincharauli, G.P., 1967: Fruit-bearing of the juniper and its significance for the food supply of animals and birds. The clear forest belt differs from other belts in terms of its bioecological conditions. This type of forest was more widespread in Georgia formerly than it is at present. The area of distribution of clear forest decreases constantly. In the arid...

Batiashvili, I.D.; Dekanoidze, G.I., 1963: Study of the connection between the varietal features of pip fruit crops and the degree of attraction and damage by the apple worm Fifth conference of the All-Union Entomological Society, 1963. Study of the connection between the varietal features of pip fruit crops and the degree of attraction and damage by the apple worm (Carpocapsa pomonella) Fifth conference of the All-Union Entomological Society, K izucheniyu svyazi sortovykh osobennostei semechkovykh plodovykh kul'tur so stepen'yu privlekaemosti i povrezhdaemosti yablonnoi plodozhorko In: Pyatoe soveshchanie Vsesoyuznogo entomologicheskogo obshchestva, Fifth conference of the All-Union Entomological Society

Wellis D.P.; Scott J.W., 1987: Odor induced responses of morphologically identified rat olfactory bulb neurons. Society for Neuroscience Abstracts 13(2): 1411

Watanabe, H.; Kakihana, M.; Ohtsuka, S.; Sugishita, Y., 1998: Efficacy and rebound phenomenon related to intermittent nitroglycerin therapy for the prevention of nitrate tolerance. Intermittent transdermal therapy of nitroglycerin (NTG) has been recommended for the prevention of nitrate tolerance, but a rebound phenomenon has been reported to occur following removal of the NTG tape. The present study investigated the effects...

Mossel, D.A.A.; Kleynen-Semmeling, A.M.C.; Vincentie, H.M.; Beerens, H.; Catsaras, M., 1970: Oxytetracycline- glucose- yeast extract agar for selective enumeration of moulds and yeasts in foods and clinical material. Oxytetracyline/glucose/yeast extract agar described previously was tested for its selectivity in the isolation of yeasts and moulds from -3500 food samples (including dried milk) which contained large numbers of Bacillus spores but few moulds and...

Midthun K.; Valdesuso J.; Kapikian A.Z.; Hoshino Y.; Green K.Y., 1989: Identification of serotype 9 human rotavirus by elisa with monoclonal antibodies. Hybridomas producing monoclonal antibodies to VP7, a major neutralizing protein of serotype 9 rotavirus (strain WI61), were prepared. One monoclonal antibody, WI61-6A1, was shown to neutralize only serotype 9 rotavirus strains and reached specific...