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Novel cyclic hexapeptides from marine-derived fungus, Aspergillus sclerotiorum PT06-1

, : Novel cyclic hexapeptides from marine-derived fungus, Aspergillus sclerotiorum PT06-1. Organic Letters 11(22): 5262-5265

Two novel cyclic hexapeptides containing both anthranilic acid and dehydroamino acid units, sclerotides A (1) and B (2), were isolated from the marine-derived halotolerant Aspergillus sclerotiorum PT06-1 in a nutrient-limited hypersaline medium. Both 1 and 2 are photointerconvertible and could be interconverted via a radical reaction initiated by direct photoisomerization. Both compounds showed moderate antifungal activity. Compound 2 also showed weak cytotoxicity and antibacterial activity.


PMID: 19827766

DOI: 10.1021/ol902197z

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