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Novel dihydrothieno[2,3-e]indazole derivatives as IκB kinase inhibitors


, : Novel dihydrothieno[2,3-e]indazole derivatives as IκB kinase inhibitors. Bioorganic & Medicinal Chemistry Letters 21(6): 1758-1762

Synthesis, and structure-activity relationship (SAR) studies of the novel IKK-β inhibitors 2 and 3 characterized by a dihydrothieno[2,3-e]indazole core are presented. Compound 2t was efficacious in a mouse model of LPS-stimulated TNF-α production.

US$19.90

PMID: 21316233

DOI: 10.1016/j.bmcl.2011.01.069


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