geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Nutrient shielding in clusters of cells


, : Nutrient shielding in clusters of cells. Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics 87(6): 062703-062703

Cellular nutrient consumption is influenced by both the nutrient uptake kinetics of an individual cell and the cells' spatial arrangement. Large cell clusters or colonies have inhibited growth at the cluster's center due to the shielding of nutrients by the cells closer to the surface. We develop an effective medium theory that predicts a thickness ℓ of the outer shell of cells in the cluster that receives enough nutrient to grow. The cells are treated as partially absorbing identical spherical nutrient sinks, and we identify a dimensionless parameter ν that characterizes the absorption strength of each cell. The parameter ν can vary over many orders of magnitude among different cell types, ranging from bacteria and yeast to human tissue. The thickness ℓ decreases with increasing ν, increasing cell volume fraction φ, and decreasing ambient nutrient concentration ψ(∞). The theoretical results are compared with numerical simulations and experiments. In the latter studies, colonies of budding yeast, Saccharomyces cerevisiae, are grown on glucose media and imaged under a confocal microscope. We measure the growth inside the colonies via a fluorescent protein reporter and compare the experimental and theoretical results for the thickness ℓ.

US$19.90

PMID: 23848711

DOI: 10.1103/PhysRevE.87.062703


Other references

Berod, T.; Mathiot, I., 1995: Importance of dosage estimation in pharmacokinetic software USC PACK PC for digoxin toxicity: apropos of a case. Therapie 50(2): 169-170

Anonymous, 1976: Should agricultural land be protected?. The article is based on the OECD report Land use policies and agriculture (WAERSA 19, 79).

Mokhtarzadeh, A.; Dolatabadi, J.Ezzati.Nazhad.; Abnous, K.; de la Guardia, M.; Ramezani, M., 2015: Nanomaterial-based cocaine aptasensors. Up to now, many different methods have been developed for detection of cocaine, but most of these methods are usually time-consuming, tedious and require special or expensive equipment. Therefore, the development of simple, sensitive and rapid det...

Katz, M.H.G.; Ahmad, S.; Nelson, H., 2013: Borderline resectable pancreatic cancer: pushing the technical limits of surgery. Bulletin of the American College of Surgeons 98(1): 61-63

Carter, MA.; Thorp, CH., 1979: The reproduction of Actinia equina L. var. mesembryanthemum. Journal of the Marine Biological Association of the United Kingdom, 594: 989-1001

Scott, A.; Christie, M.; Midmore, P., 2004: Impact of the 2001 foot-and-mouth disease outbreak in Britain: implications for rural studies. This paper assesses the impact of the 2001 foot and mouth disease outbreak in the UK in terms of its implications for the discipline of rural studies. In particular, it focuses on the position of agriculture in rural economy and society, the stand...

Fimognari, F.Luca.; D.S.mone, S.; Corsonello, A.; Pastorelli, R.; Sampietro, F.; Loffredo, L.; Violi, F.; D'Angelo, A., 2011: Poor vitamin B6 status: a novel potential thrombotic factor in chronic obstructive pulmonary disease. Nutrition, Metabolism, and Cardiovascular Diseases 20(9): E17-E18

Carneiro, A.J. de Souza., 1908: Mammiferos do Estado da Bahia. Unknown

Holgiun Velez, L.; Monteoliva Hernandez, M., 1965: Las pirofosfatas de los parasitos intestinales. II. Inhibicion por agentes farmalogicos. Revista Iberica de Parasitologia, 25: 289-298

Lomasney, J.W.; Hirakata, A.; Allen, L.F.; Capel, D.; Proia, A.D.; Caron, M.G.; Lefkowitz, R.J., 1992: Characterization of the signal transduction pathways of the three alpha-1-adrenergic receptors. Society for Neuroscience Abstracts 18(1-2): 589