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Observations on use of montelukast in pediatric eosinophilic esophagitis: insights for the future


, : Observations on use of montelukast in pediatric eosinophilic esophagitis: insights for the future. Diseases of the Esophagus 24(4): 229-234

Eosinophilic esophagitis is characterized by dense infiltration of the esophageal epithelium with eosinophils, typically accompanied by dysphagia. Effective therapies include the use of topical and systemic steroids as well as elimination diets. No previous reports have described the use of montelukast in the management of pediatric eosinophilic esophagitis. We retrospectively reviewed the charts of all patients with eosinophilic esophagitis followed in our pediatric center between 2000 and 2009. Those treated with montelukast were studied in detail. Study outcome was clinical response rate, defined by symptom (not histologic) improvement. Twenty-one patients with eosinophilic esophagitis were identified. Eight patients were maintained on montelukast (range 4-10 mg daily) after confirming the diagnosis of eosinophilic esophagitis histologically and failing to respond to a trial of proton pump inhibitor therapy. Three of eight patients had a clinical response (one had complete response and two with partial response) that could be attributed to montelukast. Four other patients responded clinically, but other therapies were concomitantly implemented. No side effects were reported with montelukast treatment with a mean follow-up duration of 32 months. Five patients had remained on montelukast therapy at the time of the final follow-up. Montelukast has minimal risk of adverse reactions compared with steroid therapy and may offer clinical relief in a small subset of children with eosinophilic esophagitis. Histologic response could not be verified in this study. Prospective studies, using higher montelukast doses, may potentially play a role and should be considered for future investigation.

US$19.90

PMID: 21073625

DOI: 10.1111/j.1442-2050.2010.01134.x


Other references

Arbeitskreis Technol Ind Gewinnung Verarb Speisefetten (W.Ger), 1990: Survey by a working party of the dgf west german society for fat science 111 steaming of edible fats and oils for deodorization and deacidification vi. Fett Wissenschaft Technologie 92(3): 115-118

Pyko, I.; Wisshak, M.; Bellou, N.; Freiwald, A., 2009: Who is boring? An experimental study of bioerosion in the eastern Mediterranean Sea. Terra Nostra (Bonn)

Cotanche, D.A.; Petrell, A.; Picard, D.A., 1991: Structural reorganization of hair cells and supporting cells during noise damage, recovery and regeneration in the chick cochlea. Exposure of the chick cochlea to intense acoustic overstimulation leads to rapid changes in the structural organization of hair cells and supporting cells. During the noise exposure the surface areas of the hair cells are reduced and, concomitantl...

von Weizsäcker, F., 1994: Principles of gene therapy. Der Internist 35(2): 123-129

Hopkins, W.D.; Misiura, M.; Pope, S.M.; Latash, E.M., 2016: Behavioral and brain asymmetries in primates: a preliminary evaluation of two evolutionary hypotheses. Contrary to many historical views, recent evidence suggests that species-level behavioral and brain asymmetries are evident in nonhuman species. Here, we briefly present evidence of behavioral, perceptual, cognitive, functional, and neuroanatomica...

Warren, J.B.; Maltby, N.H.; MacCormack, D.; Barnes, P.J., 1989: Pulmonary endothelium-derived relaxing factor is impaired in hypoxia. 1. The vasoconstrictor and vasodilator activity of cultured bovine pulmonary artery endothelial cells was measured to determine how exposure to different partial pressures of O2 [PO2 142,42 and 15 mmHg (18.9, 5.6 and 2 kPa)] affects the production...

Schmidt, S.L.; Foissner, W.; Schlegel, M.; Bernhard, D., 2007: Molecular phylogeny of the Heterotrichea (Ciliophora, Postciliodesmatophora) based on small subunit rRNA gene sequences. A comprehensive molecular analysis of the phylogenetic relationships within the Heterotrichea including all described families is still lacking. For this reason, the complete nuclear small subunit (SSU) rDNA was sequenced from further representati...

Loverde, P.T., 1976: Stereo-scan observations on the cercaria of Schistosoma haematobium. The scanning electron microscope was employed to observe the hinge region and excretory canal of the cercaria of Schistosoma haematobium.

Ahmed, Zubair, 2013: Disaster risks and disaster management policies and practices in Pakistan A critical analysis of Disaster Management Act 2010 of Pakistan. Human suffering has multiplied in recent years due to increased frequency and intensity of natural hazards, which are expected to rise in the coming years due to climate change. Admittedly, risks to humans from natural hazards cannot be eliminated...

Chen, J.; Rosebury, W.; Robertson, A.; Bocan, T.; Rekhter, M., 2000: Laser capture microdissection of paraffin embedded specimens for mRNA analysis. FASEB Journal 14(4): A459, March 15