+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Oleoylethanolamide affects food intake and sleep-waking cycle through a hypothalamic modulation

, : Oleoylethanolamide affects food intake and sleep-waking cycle through a hypothalamic modulation. Pharmacological Research 61(5): 379-384

Oleoylethanolamide (OEA) is an endogenous molecule related to endocannabinoids (eCBs) that induces satiety. It binds to the peroxisome-proliferator-activated receptor alpha (PPAR alpha). PPAR alpha is involved in feeding regulation and it has been proposed to play a role in sleep modulation. The objective of the present work is to show if this molecule modifies the sleep-waking cycle through central mechanisms. We have found that the peripheral administration of OEA reduces food intake and increases waking with a concomitant reduction of rapid eye movement sleep. Additionally, this treatment produces deactivation of the lateral hypothalamus, as inferred from the c-Fos expression evaluation. Finally, intra-lateral hypothalamus injection of OEA has mirrored the effects induced by this molecule when it is peripherally administered. In conclusion, we show for the very first time that OEA can modify the sleep-waking cycle and food intake, apparently mediated by the lateral hypothalamus.


PMID: 20100574

DOI: 10.1016/j.phrs.2010.01.010

Other references

Baggiolini, M.; Grob, H.; Bourguinet, P., 1961: Observations sur la biologie de Argyrotaenia (Eulia) pulchellana Hw. (Lep. Tortric.), ravageur nouveau des arbres fruitiers et de la vigne en Valais central. The following is based on the authors' summary. In the last few years, an indigenous Tortricid, Argyrotaenia pulchellana (Haw.), has caused sporadic damage to apple, apricot and grape vines in parts of Valais, in Switzerland. There are two ge...

Sofikitis, N.; Takenaka, M.; Kanakas, N.; Papadopoulos, H.; Yamamoto, Y.; Drakakis, P.; Miyagawa, I., 2001: Effects of cotinine on sperm motility, membrane function, and fertilizing capacity in vitro. We evaluated the effect of cotinine on sperm fertilizing capacity in vitro. Human spermatozoa were washed and re-suspended in medium containing albumin and various concentrations of cotinine (0, 100, 200, 400, or 800 ng/ml). After an 8-h incubatio...

Yoshizaki, A.; Nakayama, T.; Yamazumi, K.; Yakata, Y.; Taba, M.; Sekine, I., 2006: Expression of interleukin (IL)-11 and IL-11 receptor in human colorectal adenocarcinoma: IL-11 up-regulation of the invasive and proliferative activity of human colorectal carcinoma cells. Previous investigations have shown that interleukin (IL)-11/IL-11 receptor alpha-chain (IL-11R alpha), a member of the PI3K, MAPK and JAK-STAT activating family of cytokines/ receptors, correlates with the regulation of tumor progression. In this...

Stoop, N.; Teunis, T.; Ring, D.; Eberlin, K.R., 2017: Variation in the Rate of Surgery for Ulnar Collateral Ligament Injury of the Metacarpophalangeal Joint of the Thumb. The indications for repair of rupture of the ulnar collateral ligament (UCL) of the metacarpophalangeal (MP) joint of the thumb are debated. We studied factors predictive of operative treatment. In this retrospective study, we queried the research...

Thirion J.; Wattiaux R., 1984: Endocytosis of sucrose by surviving hepatocytes. Archives Internationales de Physiologie et de Biochimie 92(3): B107-B108

Bouchard, R.; Dana, N.; D.B.ase, L.; Natale, A.; Emelianov, S., 2012: Photoacoustic Characterization of Radiofrequency Ablation Lesions. NlmCategory="UNASSIGNED">Radiofrequency ablation (RFA) procedures are used to destroy abnormal electrical pathways in the heart that can cause cardiac arrhythmias. Current methods relying on fluoroscopy, echocardiography and electrica...

Katrusiak, A.; Katrusiak, A.; Baloniak, S., 1994: Reactivity of 6-chloro-4- and 5-hydrazino-2-phenyl-3 -pyridazinones with Vilsmeier reagent. Tetrahedron 50(45): 12933-12940

V.D.c, N.; Dubois, G.; Gervois, P.; Fruchart, J.C.arles; Laine, B.; Staels, B., 2000: Regulation of human apo-AII promoter by the orphan nuclear receptor ROR-alpha is mediated through PPAR-alpha acting as a docking factor. Circulation 102(18 Supplement): II 293, October 31

Cortes Jorge; Guzman Hector, 1985: Coral reefs of the Atlantic coast of Costa Rica. Brenesia 23: 275-292

Paepen, J.; Dirican, A.; Marouli, M.; Pommé, S.; Van Ammel, R.; Stroh, H., 2013: A magnet system for the suppression of conversion electrons in alpha spectrometry. A new magnet system has been designed and constructed to reduce coincidence effects between alpha particles and conversion electrons in high-resolution alpha-particle spectrometry. By means of a magnetic field, the conversion electrons are deflect...