+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Olfactory neuroblastoma in dogs and cats--a histological and immunohistochemical analysis

, : Olfactory neuroblastoma in dogs and cats--a histological and immunohistochemical analysis. Journal of Comparative Pathology 146(2-3): 152-159

Olfactory neuroblastoma (ONB) was identified in 13 dogs and nine cats. The tumours were subjected to microscopical examination and were graded using a human pathological grading system. In the canine and feline tumours there was more necrosis and higher mitotic activity (mitotic index and Ki67 labelling index) than reported in human ONB. Rosettes were a common feature of feline ONBs. A significant correlation was observed between the histological grade and the Ki67 labelling index. The histopathological diagnosis of ONB was confirmed immunohistochemically by demonstration of the neuronal marker neuron-specific enolase (NSE). Two other neuron-specific antibodies specific for microtubule-associated protein-2 (MAP-2) and neuronal nuclei antigen (NeuN) were evaluated. MAP-2 expression proved to have higher specificity than labelling for NSE. NeuN expression was less sensitive and of limited practical value.


PMID: 21783199

DOI: 10.1016/j.jcpa.2011.06.002

Other references

Sakurai, R.; Fujiwara, Y.; Saito, K.; Fukaya, T.; Kim, M-Ji.; Yasunaga, M.; Kim, H.; Ogawa, K.; Tanaka, C.; Tsunoda, N.; Muraki, E.; Suzuki, K.; Shinkai, S.; Watanabe, S., 2014: Effects of a comprehensive intervention program, including hot bathing, on overweight adults: a randomized controlled trial. The objective of this study was to evaluate the effects of a comprehensive overweight intervention program, which utilizes hot bathing, on overweight, community-dwelling middle-aged and older adults in a randomized controlled trial. The program wa...

Mohan N.L.; Roest W.R.; Verhoef J.; Pilkington M., 1993: Magnetic interpretation using the 3-D analytic signal; discussion and reply. Geophysics: , Pages 1214-1216. 1993.

Trinchieri, G., 1998: Proinflammatory and immunoregulatory functions of interleukin-12. Interleukin-12 (IL-12) is a cytokine composed of two chains, a heavy chain or p40, and a light chain or p35, forming a disulfite-linked heterodimer, or p70. IL-12 was originally discovered as a product of human B lymphoblastoid cell lines; however...

Weinsier, R.L.; Krumdieck, C.L., 1981: Death resulting from overzealous total parenteral nutrition: the refeeding syndrome revisited. Although cachectic patients are relatively well adapted to their calorically deprived state, they are prone to acute metabolic imbalances when infused with hypertonic solutions of dextrose and amino acids. Of particular concern is hypophosphatemia...

Caron, K.H.; Strife, J.L.; Babcock, D.S.; Ryckman, F.C., 1992: Left-lobe hepatic transplants: spectrum of normal imaging findings. The limited availability of suitable size-matched donor whole organs has been a major cause of morbidity and mortality in infants and children requiring liver transplantation. Techniques for transplanting segments of the liver have successfully ad...

Boss J.H.; Koren G.; Rosenmann E., 1979: Semi quantitative determination of liver specific antigen in the urine of rats with toxic hepatic necrosis. Using Mancini's single radial immunodiffusion technique, the excretion of a liver specific saline soluble antigen was semiquantitatively assayed in the urine of rats with thioacetamine induced hepatic necrosis. The relative amounts of antigen...

Cameron, R.H., 1945: Progress of native cattle at the African Veterinary Training Center, Sangalo, North Kavirondo, 1933-1942. The native Zebu breeding herd at Sangalo numbered -75 head in 1942. The av. daily milk yield was 7.9 lb., compared with 5.1 lb. in 1933, and the av. lactation period 227 days, compared with 75 days ten years previously. The av. butterfat content o...

Parr, James F.Reviewer, 1983: Heavy metal pollution in soils of Japan (book review). Journal of Environmental Quality 12: 6

Kawase, K.; Miyamoto, T., 1992: Detection of HTLV-1 proviral DNA with nested PCR. Nihon Rinsho. Japanese Journal of Clinical Medicine 50 Suppl: 301-304

Wang, Y.; Zhang, H.; Yao, X.; Zhao, H., 2013: Theoretical understanding and prediction of lithiated sodium hexatitanates. Sodium hexatitanates (Na(2)Ti(6)O(13)) with tunnelled structures have been experimentally proposed to be good candidates for anode materials of lithium ion batteries because of their low potential, small shape transformation, and good reversibilit...