geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

One-step bone marrow-derived cell transplantation in talar osteochondral lesions


, : One-step bone marrow-derived cell transplantation in talar osteochondral lesions. Clinical Orthopaedics and Related Research 467(12): 3307-3320

The ideal treatment of osteochondral lesions is debatable. Although autologous chondrocyte implantation provides pain relief, the need for two operations and high costs has prompted a search for alternatives. Bone marrow-derived cells may represent the future in osteochondral repair. Using a device to concentrate bone marrow-derived cells and collagen powder or hyaluronic acid membrane as scaffolds for cell support and platelet gel, a one-step arthroscopic technique was developed for cartilage repair. We performed an in vitro preclinical study to verify the capability of bone marrow-derived cells to differentiate into chondrogenic and osteogenic lineages and to be supported onto scaffolds. In a prospective clinical study, we investigated the ability of this technique to repair talar osteochondral lesions in 48 patients. Minimum followup was 24 months (mean, 29 months; range, 24-35 months). Clinical results were evaluated using the American Orthopaedic Foot and Ankle Society (AOFAS) score and the influence of scaffold type, lesion area, previous surgeries, and lesion depth was considered. MRI and histologic evaluation were performed. The AOFAS score improved from 64.4 +/- 14.5 to 91.4 +/- 7.7. Histologic evaluation showed regenerated tissue in various degrees of remodeling although none showed entirely hyaline cartilage. These data suggest the one-step technique is an alternative for cartilage repair, permitting improved functional scores and overcoming the drawbacks of previous techniques. Level IV, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.

US$19.90

PMID: 19449082

DOI: 10.1007/s11999-009-0885-8


Other references

Silcock, W.R., 1972: Lactose: its synthesis and secretion by the mammary gland. Literature relating to the synthesis and secretion of lactose by the alveolar cells of the mammary gland is reviewed. Connections between the secretion of K, lactose and protein into milk are examined, and experiments were performed using ouabain...

Osawa M.; Kobayashi I.; Takemiya T.; Murayama S., 1987: L dopa induced asterixis a clinical and physiological study. A 69-year-old woman with some sequelae of cerebrovascular disorder (CVD) had parkinsonian symptoms and signs (stage III on the scale on Hoehn and Yahr) associated with mild dementia. She developed insomnia during the first month of treatment with...

Zolotnitskaya R.P.; Drozd T.N.; Uzyanova V.L.; Zhavoronkova L.Yu; Kovanov V.V.; Shatikhin A.I.; Nikolaeva T.V., 1982: Clinical and morphological characteristics of the unconjugated hyper bilirubinemia syndrome. Fifty patients with unconjugated hyperbilirubinemia (UHB) were subjected to a comprehensive examination in order to study the difficulties encountered in diagnosing the diseases accompanied by UHB and the necessity of making a differential diagnos...

du Bocage, M., 1864: M. du Bocage, Proc. Zool. Soc. 1864, June 14, enumerates the sharks of Dr. Gray's group Acanthiana,. M. du Bocage, Proc. Zool. Soc. 1864, June 14, enumerates the sharks of Dr. Gray's group Acanthiana, which are found on the coast of Portugal, and describes the following new species and genera:-Centrophorus lusitanicus, p. 260, fig. 1; C. cre...

González-Vega, J.C.; Walk, C.L.; Stein, H.H., 2016: Effects of microbial phytase on apparent and standardized total tract digestibility of calcium in calcium supplements fed to growing pigs. An experiment was conducted to test the hypothesis that differences in the apparent total tract digestibility (ATTD) and standardized total tract digestibility (STTD) of Ca exist among Ca supplements and that inclusion of microbial phytase increas...

Subramaniam, K.; Greenfield, P.F.; Ho, K.M.; Johns, M.R.; Keller, J., 1994: Efficient biological nutrient removal in high strength wastewater using combined anaerobic-sequencing batch reactor treatment. Water Science & Technology 30(6): 315-321

Stone, P.A.; Madden, J.W., 1975: Biological factors affecting wound contraction. Surgical Forum 26: 547-548

Bates, H.E.; Sirek, A.S.; Kiràly, M.A.; Yue, J.T.Y.; Goche Montes, D.; Matthews, S.G.; Vranic, M., 2008: Adaptation to mild, intermittent stress delays development of hyperglycemia in the Zucker diabetic Fatty rat independent of food intake: role of habituation of the hypothalamic-pituitary-adrenal axis. Hypothalamic-pituitary-adrenal (HPA) axis hyperactivity occurs in type 2 diabetes, and stress is assumed to play a causal role. However, intermittent restraint stress, a model mimicking some mild stressors, delays development of hyperglycemia in...

Zalewski, J.; Dadan, H., 1979: Intraoperative cholangioscopy. Polski Przeglad Chirurgiczny 51(11): 1065-1069

Marxkors, R., 1965: Prosthetic Correction Of Traumatically Injured Front Teeth In Children And Adolescents. Ddz. das Deutsche Zahnarzteblatt 19: 74-76