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Optimising diffusion-weighted MR imaging for demonstrating pancreatic cancer: a comparison of respiratory-triggered, free-breathing and breath-hold techniques

, : Optimising diffusion-weighted MR imaging for demonstrating pancreatic cancer: a comparison of respiratory-triggered, free-breathing and breath-hold techniques. European Radiology 22(10): 2186-2192

To compare respiratory-triggered, free-breathing, and breath-hold DWI techniques regarding (1) image quality, and (2) signal intensity (SI) and ADC measurements in pancreatic ductal adenocarcinoma (PDAC). Fifteen patients with histopathologically proven PDAC underwent DWI prospectively at 1.5 T (b = 0, 50, 300, 600 and 1,000 s/mm(2)) with the three techniques. Two radiologists, independently and blindly, assigned total image quality scores [sum of rating diffusion images (lesion detection, anatomy, presence of artefacts) and ADC maps (lesion characterisation, overall image quality)] per technique and ranked them. The lesion SI, signal-to-noise ratio, mean ADC and coefficient of variation (CV) were compared. Total image quality scores for respiratory-triggered, free-breathing and breath-hold techniques were 17.9, 16.5 and 17.1 respectively (respiratory-triggered was significantly higher than free-breathing but not breath-hold). The respiratory-triggered technique had a significantly higher ranking. Lesion SI on all b-values and signal-to-noise ratio on b300 and b600 were significantly higher for the respiratory-triggered technique. For respiratory-triggered, free-breathing and breath-hold techniques the mean ADCs were 1.201, 1.132 and 1.253 × 10(-3) mm(2)/s, and mean CVs were 8.9, 10.8 and 14.1 % respectively (respiratory-triggered and free-breathing techniques had a significantly lower mean CV than the breath-hold technique). In both analyses, respiratory-triggered DWI showed superiority and seems the optimal DWI technique for demonstrating PDAC. • Diffusion-weighted magnetic resonance imaging is increasingly used to detect pancreatic cancer • Images are acquired using various breathing techniques and multiple b-values • Breathing techniques used: respiratory-triggering, free-breathing and breath-hold • Respiratory-triggering seems the optimal breathing technique for demonstrating pancreatic cancer.


PMID: 22549106

DOI: 10.1007/s00330-012-2469-3

Other references

Dale, P.J., 1994: The relative safety of transgenic and non-transgenic plants How do we assess it?. In Vitro Cellular & Developmental Biology Animal 30A(3 PART 2): 35-36

Machtinger, L.; Telford, S.R.; Inducil, C.; Klapper, E.; Pepkowitz, S.H.; Goldfinger, D., 1993: Treatment of babesiosis by red blood cell exchange in an HIV-positive, splenectomized patient. Babesiosis is a malaria-like parasitic disease causing subclinical or mild illness in most cases. Splenectomized patients, however, may experience a more severe course. Although generally responsive to antibiotic therapy, several cases of severe b...

Giannelli, F.; Cattaneo, E., 1965: Clinical Observations On Some Cases Of Encephalitis Due To Epidemic Parotitis. Giornale di Malattie Infettive E Parassitarie 17: 247-249

Powers, C.; Stay, F.; Sanville, W., 1975: Water pollution--aquatic sediments. Journal 47 (6) 1611-1617

Stalmach, V.; Smahovsky, V.; Pechova, A.; Valachovic, P.; Kmecova, J., 1998: Monitoring of 10-deacetylbaccatin III content of Slovak yew (Taxus baccata L.). Wild and ornamental yew trees growing in Slovakia were investigated for their 10-deacetylbaccatin III (precursor for taxol semisynthesis) content in 1998. The highest content was found for trees in a natural population at Becherovska Tisina (n=17,...

Dunlop, S.J.C., 1947: Investigations on the occurrence of bacteriophage-free spores of Bacillss megatherium 899 of den Dooren de Jong (transl.). Acta Leidensia 18: 82-86

Klein, J.D.; Slap, G.B.; Elster, A.B.; Schonberg, S.K., 1992: Access to health care for adolescents. A position paper of the Society for Adolescent Medicine. Journal of Adolescent Health 13(2): 162-170

Ischer, A.; Messerli, M., 1982: Game possibilities in nursing education. Krankenpflege. Soins Infirmiers: 30-41

Anderson, C.A., 1963: Quantitative Chromatographie separation of total organic phosphorus from soil extracts. Total organic-P is separated from the soil extract by sorption on 4g Norit-A decolourizing carbon. Before use the carbon is washed successively with concentrated HC1, 95% alcohol, 6n NH4OH & concentrated HC1. Inorganic P is eluted from the columns...

Bajenova, O.; Stopler, E.; Gapon, S., 2003: Surface expression of heterogeneous nuclear RNA binding protein M4 on Kupffer cell relates to its function as a carcinoembryonic antigen receptor. Elevated concentrations of carcinoembryonic antigen (CEA) in the blood are associated with the development of hepatic metastases from colorectal cancers. Clearance of circulating CEA occurs through endocytosis by liver macrophages, Kupffer cells....