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Oral administration of the flavonoid myricitrin prevents dextran sulfate sodium-induced experimental colitis in mice through modulation of PI3K/Akt signaling pathway


, : Oral administration of the flavonoid myricitrin prevents dextran sulfate sodium-induced experimental colitis in mice through modulation of PI3K/Akt signaling pathway. Molecular Nutrition & Food Research 57(11): 1938-1949

We investigated the protective effect of the flavonoid myricitrin in dextran sulfate sodium (DSS) induced colitis as promising candidate for the treatment of ulcerative colitis which is considered an important worldwide public health problem. Male CD1 mice were provided with a solution of filtered water containing 3% w/v DSS ad libitum over a 5-day period followed by 2 days with normal drinking water. Myricitrin was administered orally, once a day, at the doses 1, 3, and 10 mg/kg of body weight. At the end of day 7th, the animals were euthanized and the colonic tissue was collected to be analyzed by RT-PCR, immunohistochemistry and Western blot. Our results showed that oral treatment with myricitrin exerts consistent anti-inflammatory action in DSS-induced acute colitis in mice by the inhibition of the Akt/phosphatidylinositol-3 kinase-dependent phosphorylation. Consequently, the phosphorylation of mitogen-activated protein kinases (MAPK) p38, extracellular signal-regulated protein kinase (ERK1/2), and c-Jun N-terminal kinase and of the nuclear factor B (NF-κB) was reduced and prevented an increase in the cytokines/chemokines levels. Together, these data reveal that the anti-inflammatory effect of myricitrin in DSS-induced colitis in mice is likely associated with its ability to prevent the activation of upstream kinases, such as phosphatidylinositol-3 kinase-dependent Akt, NF-κB, and mitogen-activated protein kinase.

US$19.90

PMID: 23861337

DOI: 10.1002/mnfr.201300134


Other references

Noldart A.J., 1971: Proposed basalt quarry, Parkholme Estate, Bridgewater. Estimation of reserves, Tasmania.

Franasiak, J.M.; Lara, E.E.; Pellicer, A., 2017: Vitamin D in human reproduction. Vitamin D deficiency has been associated with a wide range of human disease states and the global epidemic, particularly in reproductive aged women, has led to a focus on this complex hormones role in human reproduction. Indeed vitamin D receptors...

Ventura, M.Teresa.; Scichilone, N.; Gelardi, M.; Patella, V.; Ridolo, E., 2016: Management of allergic disease in the elderly: key considerations, recommendations and emerging therapies. The number of people over 65 is increasing around the world. At present, between 5 and 10% of allergic diseases affect the elderly. In particular, rhinitis is increasing worldwide; the presence of high comorbidity makes the therapy of asthma even...

Hefner, J.T.; Spradley, M.Kate.; Anderson, B., 2015: Ancestry assessment using random forest modeling. A skeletal assessment of ancestry relies on morphoscopic traits and skeletal measurements. Using a sample of American Black (n = 38), American White (n = 39), and Southwest Hispanics (n = 72), the present study investigates whether these data prov...

Malik, Z.; Kostenich, G.; Orenstein, A., 1997: Spectral imaging for optimizing ALA-PDT Tumor diagnosis and PDT kinetics. Photochemistry & Photobiology 65(SPEC ISSUE): 63S

Felmingham, D.; Grüneberg, R.N., 2000: The Alexander Project 1996-1997: latest susceptibility data from this international study of bacterial pathogens from community-acquired lower respiratory tract infections. The Alexander Project was established in 1992 to examine antimicrobial susceptibilities of bacterial isolates from community-acquired infections of the lower respiratory tract. Testing of a range of compounds was undertaken in a central laboratory...

Strong, S.; Steele, S.R.; Boutrous, M.; Bordineau, L.; Chun, J.; Stewart, D.B.; Vogel, J.; Rafferty, J.F.; Rafferty, J.; Steele, S.R.; Roberts, P.; Buie, W.Donald.; Varma, M.; Carmichael, J.; Ternent, C.A.; Paquette, I., 2016: Clinical Practice Guideline for the Surgical Management of Crohn's Disease. Diseases of the Colon and Rectum 58(11): 1021-1036

Vershigora, A.Iu.; Khranovs'kiĭ, V.A., 1967: On the technic of studying bacteria and their separate chemical fractions by infrared spectroscopy. Mikrobiolohichnyi Zhurnal 29(6): 523-527

Mrevlishvili G.M., 1977: Thermodynamic properties of bio polymers in the helical and coiled state in the temperature interval 4 400 kelvin. Biophysics (English Translation of Biofizika) 22(1): 186-200

Hollenberg, D.B.; Tsasis, P.; Kelley, N., 2013: CAM in Canadian hospitals: the new frontier?. The provision in hospitals of traditional, complementary and alternative medicine (TCAM), as recognized by the World Health Organization, is now widespread in many of the world's healthcare systems. As a significant part of integrative medici...