+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Osteosarcoma diagnostic delay associated with alendronate-induced pain relief

, : Osteosarcoma diagnostic delay associated with alendronate-induced pain relief. Journal of Surgical Orthopaedic Advances 21(3): 165-169

A 32-year-old man with a painful osteoblastic osteosarcoma of the right hip was initially diagnosed as having Paget's disease of bone. He was treated with alendronate for presumptive Paget's disease. The patient's bone pain was dramatically reduced by the administration of alendronate for 7 months. Following discontinuation of alendronate, his pain promptly recurred, culminating in a more thorough evaluation that led to the correct diagnosis. Despite chemotherapy, the patient succumbed to metastatic osteosarcoma. The main purpose of this publication is to report the potential for pain relief when an osteosarcoma is treated with bisphosphonate medication. Clinicians are advised not to consider an alendronate-associated pain reduction in an osteoblastic lesion as an indicator of an underlying benign process of bone. The evaluation of painful sclerotic bone lesions is briefly reviewed.


PMID: 23199947

Other references

Martínez Castro, R.M.; Vicente Vidal, J.; Andreo, L.; Baltasar, A., 2002: Non-surgical drainage of pancreatic pseudocyst. Revista Espanola de Enfermedades Digestivas 93(9): 608-609

Shabanah, E.H.; Toth, A.; Maughan, G.B., 1964: The Role Of The Autonomic Nervous System In Uterine Contractility And Blood Flow. Ii. The Role Of The Parasympathetic Neurohormone Acetylcholine In Uterine Motility And Blood Flow. American Journal of Obstetrics and Gynecology 89: 860-880

Cohen, M.M.; Morton, W.A., 1974: Cecal diverticulum strangulated in femoral hernia. Canadian Journal of Surgery. Journal Canadien de Chirurgie 17(4): 200-201

Rotmistrov M.M., 1972: The ability of some minerals to adsorb viruses from water. Mikrobiologicheskii Zhurnal (kiev): 64-65

Zhang, Y.Y.; Vik, T.A.; Ryder, J.W.; Srour, E.F.; Jacks, T.; Shannon, K.; Clapp, D.W., 1998: Nf1 regulates hematopoietic progenitor cell growth and ras signaling in response to multiple cytokines. Neurofibromin, the protein encoded by the NF1 tumor-suppressor gene, negatively regulates the output of p21(ras) (Ras) proteins by accelerating the hydrolysis of active Ras-guanosine triphosphate to inactive Ras-guanosine diphosphate. Children wit...

Braun, H.; Silberstein, W., 1940: Zur Vereinfachung der Diagnostik pathogener Darmbak-terien. Two new culture media are described which permit, in many cases, the identification of members of pathogenic intestinal bacteria by transferring them from a single colony of the original plate to these 2 media.

Rahman S.A.; Adel F.; Jagannath M.S., 1989: Role of levamisole in the induction of cell mediated immunity in experimental cecal coccidiosis of chickens. It was found that immunity against Eimeria tenella infection developed in levamisole treated groups prior to infection within two weeks and reached the peak within 3-4 weeks and showed gradual decline from the fifth week onwards and remained at si...

Nosofsky R.M., 1992: Similarity scaling and cognitive process models. Rosenzweig, M R And L W Porter (Ed ) Annual Review Of Psychology, Vol 43 X+795p Annual Reviews Inc : Palo Alto, California, Usa Illus 25-53

He, B., 2009: Functional neuroimaging of dynamic brain activation. Brain activation is distributed in 3-dimensional brain and evolves in time. This paper reviews our recent work on developing high resolution spatio-temporal functional neuroimaging methods.

Tsybalova, L.M.; Sominina, A.A.; Popova, T.L.; Filippova, I.E.; Zibina, E.A.; Bekhtereva, T.A.; Konovalova, I.I.; Voitsekhovskaya, E.M.; Semilutskaya, I.B., 1996: Phenotypic features of symptom-free carriers of the antigenic structures of influenza A virus. Highly sensitive methods for the detection of viral antigens with the use of monoclonal or polyclonal enzyme immunoassay test systems, as well as virus-specific nucleic sequences (NS-gene) in polymerase chain reaction, made it possible to establis...