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Ovarian teratoma associated with anti-N-methyl D-aspartate receptor encephalitis: a report of 5 cases documenting prominent intratumoral lymphoid infiltrates


, : Ovarian teratoma associated with anti-N-methyl D-aspartate receptor encephalitis: a report of 5 cases documenting prominent intratumoral lymphoid infiltrates. International Journal of Gynecological Pathology 31(5): 429-437

Anti-N-methyl D-aspartate receptor (NMDAR) encephalitis is a recently described severe neurological disorder predominantly affecting young women, which presents with psychosis, memory deficits, seizures, and encephalopathy, often requiring prolonged hospitalization. The condition is frequently associated with an underlying neoplasm, most often an ovarian teratoma, and in such cases appears to be a para-neoplastic, immune-mediated encephalopathy. The histologic features of the teratomas associated with anti-NMDAR encephalitis have seldom been described in detail. Therefore, in this report, we have compared ovarian teratomas (4 mature and 1 immature) from 5 patients with anti-NMDAR encephalitis with 22 sporadic control teratomas (14 mature and 8 immature) that included neuroglial elements. The encephalitis-associated tumors ranged from 0.7 to 9.5 cm diameter, and 1 case was bilateral; the second teratoma was discovered 13 mo after the first when symptoms recurred. In comparison with control teratomas, the anti-NMDAR-associated tumors showed a more marked intratumoral lymphoid infiltrate that colocalized to the mature neuroglial elements. Reactive germinal centers (3 cases) and diffuse lymphoplasmacytic infiltrates within the neuroglial matrix (4 cases), and degenerative neuronal changes (2 cases), were seen only in the anti-NMDAR-positive cases. Pathologists encountering ovarian teratomas with these distinctive reactive lymphoid elements should consider the possibility of anti-NMDAR encephalitis, particularly because the neurological symptoms may develop after tumor resection. Careful histopathologic examination may be required to identify small, radiologically occult teratomas, and to demonstrate the presence of subtle neoplastic neuroglial components in teratomas associated with anti-NMDAR encephalitis.

US$19.90

PMID: 22833082

DOI: 10.1097/PGP.0b013e31824a1de2


Other references

Lowenthal, M.N., 1978: Serial electrocardiograms in endomyocardial fibrosis. Serial electrocardiographic changes, mostly of a minor nature, occurred in two Zambians with endomyocardial fibrosis.

Li, S.; Tang, Z.; Yu, H.; Li, W.; Jiang, Y.; Wang, Y.; An, W., 2011: Administration of naked plasmid encoding hepatic stimulator substance by hydrodynamic tail vein injection protects mice from hepatic failure by suppressing the mitochondrial permeability transition. Acute liver failure is a devastating illness of various causes with considerable mortality. Hepatic stimulator substance (HSS) has been suggested for use as a protective agent against acute hepatic injury induced by chemical poisons because it has...

Naganuma Y.; Fukuuchi Y.; Koto A.; Suzuki N.; Morita Tsuzuki Y.; Isozumi K.; Gotoh J.; Senda R., 1992: Effect of locus ceruleus lesions on the pericapillary nerve terminals in the feline brain. The effects of bilateral locus ceruleus (LC) lesions on the pericapillary nerve terminals were investigated in the feline brain parenchyma using electron microscopy. LC lesions were induced stereotaxically and the animals were sacrificed after int...

Kale, P.; Wankhade, R., 1981: Genetic variability and correlation studies in brinjal (Solanum melongena L.). P K V research journal Punjabrao Krishi Vidyapeeth 5(1): 37-42

Liu, W.; Kim, M.Young.; Kang, Y.Jae.; Van, K.; Lee, Y-Ho.; Srinives, P.; Yuan, D.Lin.; Lee, S-Ha., 2011: QTL identification of flowering time at three different latitudes reveals homeologous genomic regions that control flowering in soybean. Since the genetic control of flowering time is very important in photoperiod-sensitive soybean (<i>Glycine max</i> (L.) Merr.), genes affecting flowering under different environment conditions have been identified and described. The ob...

Sakagami, S.F., 1971: Etho-sociological comparison between honeybees and stingless bees. Review article.

Kanno, Y.; Yoshihisa, A.; Watanabe, S.; Takiguchi, M.; Yokokawa, T.; Sato, A.; Miura, S.; Shimizu, T.; Nakamura, Y.; Abe, S.; Sato, T.; Suzuki, S.; Oikawa, M.; Saitoh, S-Ichi.; Takeishi, Y., 2016: Prognostic Significance of Insomnia in Heart Failure. Insomnia is associated with incident heart failure (HF), but the clinical significance and impact of insomnia on HF remain unclear. Consecutive 1,011 patients admitted for HF were divided into 2 groups according to the presence of insomnia: HF wit...

Laptev, V.N.; Aleksandrov, A.V., 1973: Study of the chip fiberization process. Investigates the effect of preliminary treatment of sawmill waste chips 18-30 mm long in a pressfiner on their subsequent fiberization in a disk refiner and the properties of the groundwood obtained. The preliminary mechanical treatment of the chi...

Bor, W.; Dakin, J., 2006: Education system discrimination against children with mental disorders. To describe the conceptual confusion, inconsistency and discrimination within some state and territory education systems towards children with mental disorders. Reforms are required to achieve a consistent Australia wide framework for the classifi...

Babadzhanyan, G.A. (Babadjanian, G.A.; Beknazaryan, L.G. (Beknazarian, L.G., 1979: Lethal genes in Triticum macha. Most forms of T. macha studied carried Ne1 for hybrid necrosis and Ch1r for red hybrid chlorosis, but none carried the complementary genes Ne2 and Ch2r. As regards genes for white-spotted chlorosis, all but three of the forms studied carried only...