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Over 17-month complete clinical brain response with a well-tolerated lapatinib plus capecitabine combination in a very young patient afflicted by HER2-positive metastatic breast cancer


, : Over 17-month complete clinical brain response with a well-tolerated lapatinib plus capecitabine combination in a very young patient afflicted by HER2-positive metastatic breast cancer. Tumori 99(6): 273e-277e

This report describes a case of ab initio metastatic HER2-positive breast cancer in a very young patient. The onset of breast cancer at such a young age is uncommon and could delay the diagnosis with unquestionable impact on the prognosis. Unfortunately, the patient experienced cerebral progression during first-line treatment. Indeed, brain metastases occur in about one-third of HER2-positive metastatic breast cancer patients during trastuzumab-based treatment. The small molecule lapatinib is active in established cerebral disease, and we report a complete brain response longer than expected, thanks to a well-tolerated, orally administered combination of lapatinib and capecitabine.

US$19.90

PMID: 24503802

DOI: 10.1700/1390.15467


Other references

Gibson Everett K.J.; Ransom Barbara; Ingram Robert E.L., 1980: Geochemical changes produced by weathering of soils from the dry valleys of Antarctica; a progress report. NASA Technical Memorandum 82385): 202-204

Friedman, Barry, 2011: Putting the clean in coal technology. AAPG Explorer 32.7

Frost, K.M.; Hong, N.; Lord, C., 2017: Correlates of Adaptive Functioning in Minimally Verbal Children With Autism Spectrum Disorder. Individuals with autism spectrum disorder (ASD) tend to have significant delays in adaptive functioning. In this study, the relationship between adaptive behavior and ASD symptomatology was investigated in minimally verbal, school-aged children wi...

Larsen, J., 1988: Cauliflower cultivars for summer harvesting. Results from one-year trials. Data on time (days) to harvest, length of cutting period, head weight and diameter, and numbers of useable heads and unblemished heads are presented for 14 cultivars. Ballade, Andes, White Stone, Siria and Plana were rated highly; Exponent and Whi...

Mamay S.H., 1975: Sandrewia new genus a problematical plant from the lower permian of texas and kansas usa. Review of Palaeobotany & Palynology 20(1-2): 75-84

Dixon, R.A.; Hackman, D.J., 2003: Method utilizing chemical bonding to improve the bone screw fixation interface. This invention relates to a method and materials in combination for bonding screws to a fixation plate or to a skeletal bone using chemical means. The chemicals include solvents, glues, or bonding agents, which act to improve the strength of bone...

Linde, K., 1998: Live salmonella vaccine having an increased stability. Official Gazette of the United States Patent & Trademark Office Patents 1213(2): 1680, Aug 11

Guillaumée, F.; Fanton, L.; Dubien, P.Y.; Malicier, D.; Petit, P., 1997: Approach to airway control in the 5 emergency services in Lyon. Annales Francaises D'anesthesie et de Reanimation 16(8): Fi26-Fi26

Crawford, D.W.; Rogerson, A.; Laybourn Parry, J., 1994: Respiration of the marine amoeba Trichosphaerium sieboldi determined by 14C labelling and Cartesian diver methods. Estimates of rates of respiration in the marine amoeba Trichosphaerium sieboldi were compared using 2 microtechniques; a single cell 14C labelling method and Cartesian diver respirometry. Mean volume specific rates at 20 degree C determined by the...

Zanuncio, J.C.; Saavedra, J.L.D.; Oliveira, H.N.; Degheele, D.; Clercq, P. de, 1996: Development of the predatory stinkbug Brontocoris tabidus (Signoret) (Heteroptera: Pentatomidae) on different proportions of an artificial diet and pupae of Tenebrio molitor L. (Coleoptera: Tenebrionidae). The development of the Neotropical predatory pentatomid Brontocoris tabidus on an artificial diet based on beef meat and liver was evaluated. The predator showed significantly longer nymphal development and lower adult weights on this diet than wh...