geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Overexpression of JAKMIP1 associates with Wnt/β-catenin pathway activation and promotes cancer cell proliferation in vitro


, : Overexpression of JAKMIP1 associates with Wnt/β-catenin pathway activation and promotes cancer cell proliferation in vitro. Biomedicine & PharmacoTherapy 67(3): 228-234

JAKMIP1 is a member of the recently characterized JAKMIP1 family of proteins. It has been suggested that JAKMIP1 may play a role in various cell programs, such as cytoskeleton rearrangement, cell polarization, intracellular transport or even cell signaling activities. We examined its protein expression in tumor and followed it with a model that captures its impact on activities of some tumor-linked signaling pathways as well as how its upregulation affects cell proliferation. Here, we demonstrate that JAKMIP1 is highly expressed in tumor samples than in normal tissues. Additionally, higher expression of this protein may activate Wnt signaling activity, potentiate beta-catenin accumulation and enhance proliferation of cancer cells.

US$19.90

PMID: 23481296

DOI: 10.1016/j.biopha.2013.01.003


Other references

Middlemiss, E., 1975: Further record of American purple gallinule. Ostrich, 461: 117

Jairath, M.S.; Ratan, R.S.; Gupta, B.K., 1995: Temporal behaviour of costs and margins in marketing of fruits in Himachal Pradesh. A study was conducted in the north western hill region of Himachal Pradesh state, India, to investigate the inter-temporal behaviour of fruit marketing costs and margins. The analysis compares the situation in 1977/78 with that of 1992/93. It indi...

Bell-Krotoski, J., 1991: Advances in sensibility evaluation. What is needed is a quick, practical, cost-effective measurement instrument that can be depended upon to provide clear and reliable information regarding normal versus abnormal function. In the future, objective measurements will enable review of...

Morishima, H.; Takita, T.; Umezawa, H., 1972: The chemical synthesis of pepstatin A. Journal of Antibiotics 25(9): 551-552

Rahmani, G.; Joyce, C.W.; Jones, D.M.; Kelly, J.L.; Hussey, A.J.; Regan, P.J., 2016: The Irish contribution to the plastic surgery literature: 21 years of publications. The Republic of Ireland has always had an influence on medicine and has produced many renowned doctors who have helped shape its history. Furthermore, many clinical articles that have originated from Ireland have changed clinical practice througho...

Marks, J.S.; Redmond, R.L., 1996: Demography of bristle-thighed Curlews Numenius tahitiensis wintering on Laysan Island. We studied the nonbreeding ecology of Bristle-thighed Curlews Numenius tahitiensis from 1988 to 1991 on Laysan Island in the Northwestern Hawaiian Islands. Using capture-recapture analysis, we estimated that 300-350 curlews wintered on the island....

Lee, R.B., 1979: Effect of phosphate deficiency on the absorption and translocation of anions by barley plants. Barley plants were grown for 11 days without P or with 0.5 mM phosphate. At the end of this time, the total P conc. in roots and shoots of P-deficient plants was c. 20% of that in the controls. The uptake and transport of 32P was then compared wit...

Berczi S.; Fabriczy A.; Hargitai H.; Hegyi S.; Illes E.; Kabai S.; Kovacs Z.; Kereszturi A.; Opitz A.; Sik A.; Varga T.; Weidinger T., 2003: Atlas series of the solar system 5 booklets and other works for education and public outreach by Cosmic Materials, Planetology and Hunveyor Groups of the Eotvos University, Hungary. Our Atlas Series consists of five booklets of interactive material in space science education: (1) Planetary petrography, (2) Surveyor-Hunveyor educational robotics, (3) planetary surfaces, (4) planetary atmospheres,.

Tomazetto, G.; Oliveira, Véria.M., 2014: Investigation of the FeFe-hydrogenase gene diversity combined with phylogenetic microbial community analysis of an anaerobic domestic sewage sludge. Biological hydrogen production through the anaerobic digestion is an environmental friendly alternative for satisfying future hydrogen demands. Microorganisms residing into waste water treatment plants are far from being exhaustively characterized...

Coxon, J.M.; Fischer, A.; Hartshorn, M.P.; Lewis, A.J.; Richards, K.E., 1969: Reactions of 3 beta-fluoro-5 alpha-hydroxy steroids. Steroids 13(1): 51-58