+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Oxidant/antioxidant status in patients with Raynaud's disease

, : Oxidant/antioxidant status in patients with Raynaud's disease. La Clinica Terapeutica 159(2): 77-81

Despite several studies concerning the oxidative stress in Raynaud's phenomenon secondary to systemic sclerosis (secondary Raynaud, SR), little is known regarding the relationship between Raynaud's disease (primary Raynaud, PR) and oxidative stress at present. The aim of the present research was to study the parameters of oxidative stress in PR patients and to compare them to those of SR patients. Serum hydroperoxide (Hydrop) level, serum total antioxidant capacity (TAC) and serum total thiol (-SHp) barrier were measured in 19 patients with SR, 15 patients with PR and 14 healthy control subjects (CS). The statistical contrasts were performed via one-way ANOVA. The serum Hydrop concentrations were significantly higher in SR (p = 0.0043) and PR (p = 0.0038) groups in comparison with CS. A significant decrease in serum TAC level in SR (p = 0.00005) and PR (p = 0.00128) patients in respect to the CS was revealed. No significant change in the -SHp barrier in SR and PR patients in respect to CS has been demonstrated. However, there were no significant differences in serum Hydrop and TAC levels between the groups of patients. The study of serum oxidative stress parameters, in terms of Hydro and TAC levels may be used as a routine and rapid test to verify the oxidative stress status in SR and PR patients and to undertake a strategy of treatments by a supplementation of antioxidant molecules.


PMID: 18463765

Other references

Hisamichi, S., 1984: Current issues and future prospects of gastric mass survey. In general, it is necessary to consider morbidity rate and mortality in the population at risk when mass survey for cancer is performed. From our long-term follow-up study, it is clearly suggested that gastric mass survey contributed toward reduci...

Nicosia M.L., 1971: Giordanella; a characteristic trilobite of the Sardinian Cambrian. Geo Archeologia: al edition, Pages 27-29. 1971.

Perfumo, CJ.; Brandetti, E.; Menendez, NA.; Petrucelli, MA., 1978: Toxoplasmosis en conejos domesticos. Analecta Veterinaria, 101: 21-27

Margolin, W., 1998: A green light for the bacterial cytoskeleton. Improved fluorescence techniques for visualizing proteins in whole bacterial cells have resulted in recent breakthroughs in our understanding of chromosome segregation and cytokinesis in prokaryotes. The dynamics and localization of some of these...

D.G.ulio, A.; Ronchi, A.; Sanfilippo, A.; Tiepolo, M.; Pimentel, M.; Ramos, V.A., 2012: Detrital zircon provenance from the Neuquen Basin south-central Andes; Cretaceous geodynamic evolution and sedimentary response in a retroarc-foreland basin. The surface response, in terms of drainage pattern changes, to the Cretaceous geodynamic reorganization of the Andean subduction zone between 36 degrees S and 41 degrees S is reconstructed through the geochronology-based provenance study of alluvi...

Marafie, E.M.; Marafie, I.; Emery, S.J.; Waters, R.; Jones, N.J., 2001: Biomonitoring the human population exposed to pollution from the oil fires in Kuwait: analysis of placental tissue using (32)P-postlabeling. The placenta is a readily available source of material for molecular epidemiological investigations. As such, DNA damage in this tissue can be indicative of maternal exposure to environmental pollutants such as polycyclic aromatic hydrocarbons (PA...

Spigset, O., 2000: From ready-made to tailor-made--future possibilities for individualized drug therapy. Knowledge of the genetic code offers great promise for individualised drug therapy. Recent advances in molecular biology and biotechnology have led to new possibilities in the prediction of therapeutic effects and risks of adverse reactions based...

Buizert, A.; Sharma, R.; Koppen, H., 2017: When the Laughing Stops: Subacute Combined Spinal Cord Degeneration Caused by Laughing Gas Use. : Here we describe a case of subacute combined spinal cord degeneration caused by nitrous oxide (N2O, laughing gas) use. Because of its euphoric effects, the use of N2O has become increasingly popular in recent years. Unfortunately, the use of N2O...

Ovezmukhammedov, A., 1974: Ecological data on intestinal Coccidia parasitizing reptiles of Turkmenistan. Izvestiya Akad Nauk turkmen SSR (Biol): 5: 64-67

Goel, D.; Subramanyam, A.; Kamath, R., 2013: A study on the prevalence of internet addiction and its association with psychopathology in Indian adolescents. There has been an explosive growth of internet use not only in India but also worldwide in the last decade. There is a growing concern about whether this is excessive and, if so, whether it amounts to an addiction. To study the prevalence of inter...