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P-Glycoprotein is not a key target for the chemosensitizing effect of 1-phenyl-2-decanoylamino-3-morpholino-1-propanol in HepG2 cells exposed to doxorubicin


, : P-Glycoprotein is not a key target for the chemosensitizing effect of 1-phenyl-2-decanoylamino-3-morpholino-1-propanol in HepG2 cells exposed to doxorubicin. Drug Metabolism Letters 4(1): 39-44

Chemosensitization of HepG2 cells to doxorubicin by 1-phenyl-2-decanoylamino-3-morpholino-1-propanol neither impinged on downregulation of P-glycoprotein expression nor on severe impairment of its activity. Moreover, differently from verapamil, a potent P-glycoprotein inhibitor, 1-phenyl-2-decanoylamino-3-morpholino-1-propanol chemosensitized HepG2 cells in a fashion that was insensitive to the pancaspase inhibitor benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone. At concentrations exceeding the one employed for chemosensitization, 1-phenyl-2-decanoylamino-3-morpholino-1-propanol was by itself strongly toxic to HepG2 cells, and also this effect was insensitive to the pancaspase inhibitor. These results suggest that 1-phenyl-2-decanoylamino-3-morpholino-1-propanol, at subtoxic concentrations, might synergize with scarcely toxic doxorubicin doses to propagate a caspase-independent cytotoxic response, such that P-glycoprotein-dependent drug resistance is circumvented.

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PMID: 20201777


Other references

Park, K.C.; Jung, H.C.; Hwang, J.H.; Youn, S.W.; Ahn, J.S.; Park, S.B.; Kim, K.H.; Chung, J.H.; Youn, J.I., 1997: GM-CSF production by epithelial cell line: Upregulation by ultraviolet A. It was demonstrated that UVB increases synthesis and expression of IL-1alpha and GM-CSF by keratinocytes. Upregulation of GM-CSF by UVB is reported to be mediated by IL-1alpha. However, regulation of IL-1alpha and GM-CSF by UVA is not well-known....

Chen, G., 1984: Family planning and economic development in Shifang County. According to Marx, population either hinders or expedites economic development. During the late 1950s and early 1960s, Shifang County's population grew unchecked. In the 1960s its annual rate of population growth was higher than the national...

Stshedrin, F.Z., 1927: Der Einfluss von Gasen auf die Farbung bei Vanessa urticae L. Revue Russe d'Entomologie, 21: 163-170

Mayerhöfer, T.G.; Weber, S.; Popp, Jürgen., 2011: Dispersion analysis of perpendicular modes in anisotropic crystals and layers. Until today dispersion analysis could not be successfully applied to evaluate oscillator parameters of modes that have their transition moments perpendicular to the surface of an anisotropic crystal or a layered medium. The main reason for this fa...

Kontessis, P.S.; Sarika, L.; Rappini, P.; Thoma, A.; Karamaliki, M.; Souvatzoglou, A., 1993: Sodium-lithium countertransport activity and intracellular sodium in IDDM women with pregnancy-induced hypertension. Nephrology Dialysis Transplantation 8(9): 940

Unger, J.B.; Bartsch, L., 2017: Exposure to tobacco websites: Associations with cigarette and e-cigarette use and susceptibility among adolescents. Exposure to tobacco advertising is a risk factor for tobacco use and susceptibility among adolescents. Although tobacco company websites are ostensibly targeted to adults, some youth access these websites and are exposed to tobacco-related content...

Harper, D.C.; Ohm, H.W.; Foster, J.E., 1979: Barley yellow dwarf resistance in oats. Seedlings of varieties, breeding lines and intervarietal crosses were tested by infesting with viruliferous Rhopalosiphum padi in 1977 and 1978. CI 9312, ILL70-1297 and Otee showed fewer symptoms of barley yellow dwarf virus than did Noble, Stout...

Bisset, A., 2008: High resolution radiometric surveying in the East Kimberley region of Western Australia. Australasian Institute of Mining and Metallurgy 5/2008: 71

Börsch, G.; Schmidt, G., 1985: Endoscopy of the terminal ileum. Diagnostic yield in 400 consecutive examinations. A prospective study was undertaken to investigate the feasibility and diagnostic yield of ileoscopy as an extension of total colonoscopy. The distal 15 to 40 cm of the terminal ileum were visualized in 400 of 555 consecutive patients submitted to...

van der Kogel, A.J., 1986: Radiation-induced damage in the central nervous system: an interpretation of target cell responses. British Journal of Cancer. Supplement 7: 207-217