geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

PLGA particle production for water-soluble drug encapsulation: degradation and release behaviour


, : PLGA particle production for water-soluble drug encapsulation: degradation and release behaviour. Colloids and Surfaces. B, Biointerfaces 75(2): 557-564

Particles for subcutaneous depot use encapsulating a model water-soluble drug have been produced from poly(lactic-glycolic acid) (PLGA) using a membrane emulsification-solvent evaporation technique. The release behaviour, mainly the change in size and inner morphology are reported. During release, the particles initially swelled in size, then reduced. A diffusion based model, taking in to account the change in particle size, is presented. Surface erosion is evident from the particle size and image evidence, and the diffusion model provides a fit to the data even during the surface erosion period, suggesting that the model drug diffuses before the particle degrades.

US$19.90

PMID: 19853423

DOI: 10.1016/j.colsurfb.2009.09.035


Other references

Stamatiou, G.; Vidaurre, D.P.; Shim, I.; Tang, X.; Moeder, W.; Bonetta, D.; McCourt, P., 2013: Forward genetic screening for the improved production of fermentable sugars from plant biomass. With their unique metabolism and the potential to produce large amounts of biomass, plants are an excellent bio-energy feedstock for a variety of industrial purposes. Here we developed a high-throughput strategy, using the model plant Arabidopsis...

Abo Alchamlat, S.; Farnir, Fédéric., 2017: KNN-MDR: a learning approach for improving interactions mapping performances in genome wide association studies. Finding epistatic interactions in large association studies like genome-wide association studies (GWAS) with the nowadays-available large volume of genomic data is a challenging and largely unsolved issue. Few previous studies could handle genome-...

Curia, G.; Lucchi, C.; Vinet, J.; Gualtieri, F.; Marinelli, C.; Torsello, A.; Costantino, L.; Biagini, G., 2014: Pathophysiogenesis of mesial temporal lobe epilepsy: is prevention of damage antiepileptogenic?. Temporal lobe epilepsy (TLE) is frequently associated with hippocampal sclerosis, possibly caused by a primary brain injury that occurred a long time before the appearance of neurological symptoms. This type of epilepsy is characterized by refract...

Hahn, Y-Soo.; Taube, C.; Jin, N.; Takeda, K.; Park, J-Won.; Wands, J.M.; Aydintug, M.Kemal.; Roark, C.L.; Lahn, M.; O'Brien, R.L.; Gelfand, E.W.; Born, W.K., 2003: V gamma 4+ gamma delta T cells regulate airway hyperreactivity to methacholine in ovalbumin-sensitized and challenged mice. The Vgamma4(+) pulmonary subset of gammadelta T cells regulates innate airway responsiveness in the absence of alphabeta T cells. We now have examined the same subset in a model of allergic airway disease, OVA-sensitized and challenged mice that e...

Oliver, B., 1959: Nigeria's useful plants. Part II. Medicinal plants (2). cf. F.A. 20 Nos. 2600, 3953.] From Cassia to Fagara (ca. 70 spp.), giving notes on the chemical principles contained and their uses in European and native medicine.

Martin, B.; Wright, S., 2003: Countershock: mobilizing resistance to electroshock weapons. Electroshock, stun and restraint technologies are often used for torture and as tools of repression. There is much information available exposing the problems with such technologies, but little about how to be effective in challenging their use. T...

Puppala, B.L.; Bhalla, S.; Matwyshyn, G.; Gulati, A., 2005: Role of endothelin (ETA) receptors in neonatal morphine withdrawal. We have previously demonstrated role of central endothelin (ET) receptors in neonatal morphine tolerance. The present study was conducted to investigate involvement of central ET receptors in neonatal rat morphine withdrawal. The aim was to determ...

Becq-Giraudon, B.; Marechaud, R.; Pouget Abadie, J.F.; Sudre, Y., 1979: Paraneoplastic hypercalcaemia in a case of carcinoma of the bladder. Demonstration in the tumour of a substance with parathormone activity. Hypercalcaemia accompanied a bladder tumour in a 77-year-old woman. Immuno-reactive parathormone (IPTH) in the tumour being high, the hypercalcaemia could thus be attributed to secretion by the tumour of a substance with parathormone activity. The...

Pedersen, A.H.; Andersen, K.L., 1944: The effect of centrifuging milk before H.T.S.T. pasteurization. Tests have been carried out in order to illustrate the influence of centrifugal clarification on H.T.S.T. pasteurized milk. An ordinary separator was used as a clarifier. The milk was pasteurized at 70 to 73 degrees C. and clarified at 35 degrees...

Vanky K., 1983: 10 new species of ustilaginales. The following new species of Ustilaginales are described: Anthracoidea curvulae sp. nov. on Carex curvula, A. humilis sp. nov. on C. humilis, Entyloma arctotheca sp. nov. on Arctotheca calendula, E. sonchi sp. nov. on Sonchus asper, E. taraxaci sp...