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Palladium-catalyzed C(sp2)-H cyanation using tertiary amine derived isocyanide as a cyano source

, : Palladium-catalyzed C(sp2)-H cyanation using tertiary amine derived isocyanide as a cyano source. Organic Letters 14(18): 4966-4969

An unprecedented palladium-catalyzed cyanation of aromatic C-H bonds by using tertiary amine derived isocyanide as a novel cyano source was developed. Cu(TFA)(2) was used as a requisite stoichiometric oxidant. Mechanistic studies suggest that a tertiary carbon cation-based intermediate is involved following the C-N bond breakage.


PMID: 22937807

DOI: 10.1021/ol302372p

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