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Palladium-catalyzed cascade annulation to construct functionalized β- and γ-lactones in ionic liquids

, : Palladium-catalyzed cascade annulation to construct functionalized β- and γ-lactones in ionic liquids. Angewandte Chemie 53(28): 7219-7222

A highly efficient and mild palladium-catalyzed, one-pot, four-step cascade annulation has been developed to afford functionalized β- and γ-lactones in moderate to good yields with high regio- and diastereoselectivities in ionic liquids. The employment of ionic liquids under mild reaction conditions makes this transformation green and practical. Especially, this reaction provided a novel and convenient methodology for the construction of naturally occurring biologically active β- and γ-lactones.


PMID: 24866483

DOI: 10.1002/anie.201403341

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