+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Panax notoginseng attenuates experimental colitis in the azoxymethane/dextran sulfate sodium mouse model

, : Panax notoginseng attenuates experimental colitis in the azoxymethane/dextran sulfate sodium mouse model. PhytoTherapy Research 28(6): 892-898

Patients suffering from inflammatory bowel disease are at a high risk of developing colorectal cancer. To assess the anticancer potential of botanicals, in this study, we evaluated the effects of Panax notoginseng on azoxymethane/dextran sulfate sodium (DSS)-induced colitis. One week after A/J mice received azoxymethane, the animals received DSS for 8 days or were supplemented with P. notoginseng extract, at 30 or 90 mg/kg. DSS-induced colitis was scored with the disease activity index. The severity of the inflammatory lesions was evaluated by a colon tissue histological assessment. The expression of inducible nitric oxide synthase and cyclooxygenase-2 (COX-2) were also explored. We observed that the effects of P. notoginseng on the reduction of colon inflammation, expressed in disease activity index score, were in a dose-related manner (p < 0.01). P. notoginseng inhibited the reduction of the colon length and the loss of bodyweight in dose-related manner (all p < 0.05). The histological assessment of the colitis and inflammatory-related immunohistochemical data also supported the pharmacological observations. Our data suggest that P. notoginseng is a promising candidate in preventing and treating colitis and inflammation-associated colon carcinogenesis.


PMID: 24142591

DOI: 10.1002/ptr.5066

Other references

Nakajima, K., 2003: The mechanism of antigenic shift and drift of human influenza virus. Influenza virus has a remarkable ability in escaping host defense mechanisms by altering its the antigenic character. The molecular mechanisms by which viruses alter their antigenic character form an important subject of study since they ultimatel...

Ito, M.; Yanaga, T.; Mashiba, H., 1963: Studies On Transmembrane Potential And Sino-Caval Conduction In Mammalian Cardiac And Vascular Smooth Muscle (First Report). Kyushu Journal of Medical Science 14: 393-402

Ventola, C.Lee., 2016: Immunization in the United States: Recommendations, Barriers, and Measures to Improve Compliance: Part 2: Adult Vaccinations. Despite annual recommendations, American adults remain inadequately vaccinated. The author outlines how compliance may be improved through health care professional interventions, as well as government and community-based programs.

S.P.pova J.; Petkov V.V., 1990: Changes in 5 ht 1 receptors in different brain structures of rats with isolation syndrome. 1. Prolonged (3 month) individual housing of Wistar rats produced aggressive muricidal behavior in 28% of the animals. 2. Binding studies with [3H]5-HT showed that the affinity (Kd) of 5-HT1 receptors in the frontal cortex, striatum, hippocampus a...

Frampton, J.E., 2012: Vandetanib: in medullary thyroid cancer. Vandetanib, an orally active, small-molecule, multitargeted tyrosine kinase inhibitor, demonstrates potent inhibitory activity against vascular endothelial growth factor receptor (VEGFR)-2 and -3, epidermal growth factor receptor (EGFR) and the re...

Anonymous, 1987: Medical management of prostate cancer. A satellite symposium of the 3rd International Congress on Hormones and Cancer. Nice, France, 2-4 September 1987. Abstracts. European Journal of Cancer & Clinical Oncology 23(8): 1229-1252

Saez, F.; Macchiavello, J.; Fonck, E.; Bulboa, C., 2008: The role of the secondary attachment disc in the vegetative propagation of Chondracanthus chamissoi Gigartinales; Rhodophyta. The reattachment and vegetative growth of tetrasporophytic and cystocarpic fronds of Chondracanthus chamissoi by means of secondary attachment discs was evaluated in vitro. Our results show that both the reattachment of fronds and sprouting of ne...

Zhang, Z.; Wong, H.H.; Albertson, P.L.; Harrison, M.D.; Doherty, W.O.S.; O'Hara, I.M., 2016: Effects of glycerol on enzymatic hydrolysis and ethanol production using sugarcane bagasse pretreated by acidified glycerol solution. In this study, for the first time the effects of glycerol on enzymatic hydrolysis and ethanol fermentation were investigated. Enzymatic hydrolysis was inhibited slightly with 2.0 wt% glycerol, leading to reduction in glucan digestibility from 84.9...

Dale, D.C., 2017: President's Address: Physicians and the Pharmaceutical Industry. Transactions of the American Clinical and Climatological Association 128: 1-13

Fouilloy, R., 1974: Lauraceae, Myristicaceae, Monimiaceae. Flore du Cameroun: 18