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Pancreatic beta cell function persists in many patients with chronic type 1 diabetes, but is not dramatically improved by prolonged immunosuppression and euglycaemia from a beta cell allograft


, : Pancreatic beta cell function persists in many patients with chronic type 1 diabetes, but is not dramatically improved by prolonged immunosuppression and euglycaemia from a beta cell allograft. Diabetologia 52(7): 1369-1380

We measured serum C-peptide (at least 0.167 nmol/l) in 54 of 141 (38%) patients with chronic type 1 diabetes and sought factors that might differentiate those with detectable C-peptide from those without it. Finding no differences, and in view of the persistent anti-beta cell autoimmunity in such patients, we speculated that the immunosuppression (to weaken autoimmune attack) and euglycaemia accompanying transplant-based treatments of type 1 diabetes might promote recovery of native pancreatic beta cell function. We performed arginine stimulation tests in three islet transplant and four whole-pancreas transplant recipients, and measured stimulated C-peptide in select venous sampling sites. On the basis of each sampling site's C-peptide concentration and kinetics, we differentiated insulin secreted from the individual's native pancreatic beta cells and that secreted from allografted beta cells. Selective venous sampling demonstrated that despite long-standing type 1 diabetes, all seven beta cell allograft recipients displayed evidence that their native pancreas secreted C-peptide. Yet even if chronic immunosuppression coupled with near normal glycaemia did improve native pancreatic C-peptide production, the magnitude of the effect was quite small. Some native pancreatic beta cell function persists even years after disease onset in most type 1 diabetic patients. However, if prolonged euglycaemia plus anti-rejection immunosuppressive therapy improves native pancreatic insulin production, the effect in our participants was small. We may have underestimated pancreatic regenerative capacity by studying only a limited number of participants or by creating conditions (e.g. high circulating insulin concentrations or immunosuppressive agents toxic to beta cells) that impair beta cell function.

US$19.90

PMID: 19418039

DOI: 10.1007/s00125-009-1342-7


Other references

Marcos, M.A.; Martinez, E.; Gatell, J.M.; Tortajada, C.; Gomez, J.; D.L.B.llacasa, J.P.ig; Soriano, E.; Jimenez D.A.ta, M.T., 1997: Pharyngeal colonization by Streptococcus pneumoniae in HIV-infected patients. Clinical Infectious Diseases 25(2): 455

Mladenov, M.; Aleksieva, V.T.dorov, P.B.chiiska, M., 1984: Microbiological studies of Mlad. Veterinarno meditsinski nauki = Veterinary science1(1): 103-109

Liu, J.S.; Amemiya, R.; Chung, F.M.; Tsuboi, M.; Saito, H.; Matsushima, Y.; Hayashi, N.; Oho, K.; Hayata, Y., 1991: The present status of bronchoscopic Nd:YAG laser. In Japan, the first bronchoscopic Nd:YAG laser applied clinically was performed in our institute 10 years ago, and based on this decade of experience, the indications, effectiveness, and limitations were studied. Between 1980 and 1989, a total of...

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Silver J.G.; Martin A.W.; Mcbride B.C., 1979: Experimental transient bacteremias in human subjects with clinically healthy gingivae. Thirty-six subjects with no evidence of clinical gingival inflammation underwent a standardized toothbrushing procedure. Blood specimens, obtained from a vein in the antecubital fossa during the last 30 s of brushing, were cultured under aerobic a...

Arbuzova, K.; Stashkova, V.; Lukashevich, L.; Khoroshko, R.; Peryshkina, N., 1980: Ion-exchange substrates for plants. 8. Studies of the duration of using ion-exchange substrate in the cultivation of greens in a crop rotation regime. Agrokhimiia (2) 99-103

Seo Jeong Ryul; Hwang Duk Hwan; Yun Uk; O.M.hn Soo; Kim Seon Eok, 1998: Study on the geology and ore deposits of Miryang-Yeongsan area in Kyeongnam Province, South Korea. A detail study on the geology and ore deposits of Miryang claim No. 1, claim No. 31 and Yeongsan claim No. 110 in Kyeongnam province had carried out in 1998. Geophysical exploration and drilling exploration(3 drill holes with 410m of total length)...

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