+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Paraneoplastic syndromes in patients with nasopharyngeal cancer

, : Paraneoplastic syndromes in patients with nasopharyngeal cancer. Auris, Nasus, Larynx 36(5): 513-520

Paraneoplastic syndromes (PNS) represent the clinical manifestation of the remote and indirect effects produced by tumor metabolites or other products. Paraneoplastic effects are not directly mediated by tumor invasion of normal tissue, or by the disruption of normal function of the involved organ, or by distant metastases. More than 260 cases of nasopharyngeal carcinoma (NPC) associated with PNS have been reported in the literature. These syndromes can be divided into six main groups: cutaneous or dermatologic, endocrine, hematologic, osteoarticular or rheumatologic, neurologic, and ocular. The most common dermatologic manifestation is dermatomyositis, while the syndrome of inappropriate secretion of antidiuretic hormone and occasionally Cushing's syndrome due to ectopic ACTH production are the endocrinologic manifestations. Tumor fever and leukemoid reaction, osteoarticular or rheumatic syndromes, including clubbing of the fingers and toes, sensory neuropathy and demyelinating motor polyneuropathy, and rarely optic neuritis represent the most prominent examples of the other groups of syndromes. PNS may occur before the NPC is manifest, or while it is in an occult stage, and thus the possibility of NPC should be considered in patients with these various disorders. While some PNS will respond to direct treatment, most often the PNS subsides in parallel to response of the NPC, and thus may be useful for monitoring tumor response or recurrence.


PMID: 19111998

DOI: 10.1016/j.anl.2008.10.006

Other references

Patterson, B.D.; Paull, R.; Smillie, R.M., 1978: Chilling resistance in Lycopersicon hirsutum Humb. & Bonpl., a wild tomato with a wild altitudinal distribution. In studies of populations of L. hirsutum from Peru and Ecuador, germination rate and chlorophyll development at low temperatures and chilling resistance (measured as the ability to grow after a period of 0 deg C) were greatest in Peruvian populati...

June F.C., 1974: Ecological changes during the transitional years of final filling and full impoundment 1966 1970 of lake oahe an upper missouri river storage reservoir. U S Fish & Wildlife Service Technical Papers 71-82: 1-57

Linskens, HF., 1980: The 'third eye'.. Vakblad voor Biologen, 6015: 311-312

Morin-Surun, M.P.; Collin, T.; Denavit-Saubié, M.; Baulieu, E.E.; Monnet, F.P., 1999: Intracellular sigma1 receptor modulates phospholipase C and protein kinase C activities in the brainstem. Most physiological effects of sigma1 receptor ligands are sensitive to pertussis toxin, suggesting a coupling with cell membrane-bound G proteins. However, the cloning of the sigma1 receptor has allowed the identification of an intracellular prote...

Matsui, A.; Yokoo, H.; Negishi, Y.; Endo-Takahashi, Y.; Chun, N.A.L.; Kadouchi, I.; Suzuki, R.; Maruyama, K.; Aramaki, Y.; Semba, K.; Kobayashi, E.; Takahashi, M.; Murakami, T., 2013: CXCL17 expression by tumor cells recruits CD11b+Gr1 high F4/80- cells and promotes tumor progression. Chemokines are involved in multiple aspects of pathogenesis and cellular trafficking in tumorigenesis. In this study, we report that the latest member of the C-X-C-type chemokines, CXCL17 (DMC/VCC-1), recruits immature myeloid-derived cells and en...

Bond, M.R., 2004: Address by the new president for the future of Interdisciplinary Association of Pain Therapy. Schmerz 18(1): 80-84

Anonymous, 1996: Brief of the Attorney General in Vacco v. Quill in the United States Supreme Court. No. 95-1858. Issues in Law & Medicine 12(3): 275-294

Mesmer, F.A., 1973: Classics: memoir on the discovery of animal magnetism (Franz A. Mesmer). Actas Luso-Espanolas de Neurologia, Psiquiatria Y Ciencias Afines 1(5): 733-739

Lefèvre, R.; Goffman, M.F.; Derycke, V.; Miko, C.; Forró, L.; Bourgoin, J.P.; Hesto, P., 2005: Scaling law in carbon nanotube electromechanical devices. We report a method for probing electromechanical properties of multiwalled carbon nanotubes (CNTs). This method is based on atomic force microscopy measurements on a doubly clamped suspended CNT electrostatically deflected by a gate electrode. We...

Baskaran M.; Somayajulu B.L.K., 1986: Mineralogy of Saurashtra miliolites. Journal of the Geological Society of India 27(1): 63-89