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Partial hepatectomy improves the outcome of intraportal islet transplantation by promoting revascularization


, : Partial hepatectomy improves the outcome of intraportal islet transplantation by promoting revascularization. Islets 4(2): 138-144

Revascularization of grafts is one of the important key factors for the success of islet transplantation. After partial hepatectomy, many growth factors such as hepatocyte growth factor and vascular endothelial growth factor are increased in the remnant liver. These growth factors have properties that promote angiogenesis. This might be an optimal environment for revascularization of islets transplanted intraportally. To verify this hypothesis, syngeneic islets (330 per recipient) were transplanted into the right hepatic lobes of streptozotocin-induced diabetic Balb/c mice with (hepatectomy group) or without (control group) left liver resection. Blood glucose was monitored for 28 d after transplantation. Glucose tolerance test was performed on post-operative day (POD) 30, and histological assessments were performed on POD 7 and 30 respectively. Analysis revealed that 36.7% of the control and 90.0% of the hepatectomy mice attained normoglycemia during the observation period (*p = 0.0142). Glucose tolerance was improved in the hepatectomy group (Area under the curve of intraperitoneal glucose tolerance tests on POD 30, Control; 47,700 ± 5,890 min*mg/dl, Hepatectomy; 26,000 ± 2,060 min*mg/dl: **p = 0.00314). Revascularization of grafted islets was more pronounced in the hepatectomy group (Vessel number per islet area on POD 7, Control; 3.20 ± 0.463 × 10 (-4) /µm ( 2) , Hepatectomy; 7.08 ± 0.513 × 10 (-4) /µm ( 2) : **p < 0.01). In the present study, partial hepatectomy (30%) improved the outcome of intraportal islet transplantation. Revascularization of islets transplanted into the liver may have been promoted by the induction of liver regeneration.

US$19.90

PMID: 22622159

DOI: 10.4161/isl.19491


Other references

Ulanowicz R.E.; Kemp W.M., 1979: Toward canonical trophic aggregations. Steady-state input-output analysis of energy flows in an ecosytem delineates the discrete steps of energy processing in a given ecosystem. The fraction of a specific flow between species which results from a given input via any integral number of...

Estrada-Pena, A., 1990: Indice-catalogo de las garrapatas en el mundo. Tomo 2: Generos Anocentor, Dermacentor y Cosmiomma (Volz.). Unknown

McCullough, A.; Thomas, E.T.; Ryan, C.; Bradley, J.M.; O'Neill, B.; Elborn, S.; Hughes, C., 2016: Interventions for enhancing adherence to treatment in adults with bronchiectasis. Bronchiectasis is characterised by a widening of the airways, leading to excess mucus production and recurrent infection. It is more prevalent in women and those in middle age. Many patients with bronchiectasis do not adhere to treatments (medicat...

Thomas, V.; Ho, K.B.; Yap, P.L., 1980: Seroepidemiology of malaria in Peninsular Malaysia: Plasmodium falciparum antibody profile of adults in four states. In 1973, 2610 sera were collected from adults living in 22 localities in four states in Peninsular Malaysia and tested by IFAT for Plasmodium falciparum antibodies. A larger number of thin films were examined. The attack phase of the Malaria Eradi...

French T.A.; Masserano J.M.; Weiner N., 1990: The role of central and adrenal catecholaminergic systems in mediating trh effects on ethanol sensitivity in ls and ss mice. Alcoholism Clinical & Experimental Research 14(2): 289

Court, S.D., 1969: The future training of consultant paediatricians. The knowledge, skills, and professional attitudes required of the consultant paediatrician. British Journal of Medical Education 3(4): 332-334

Geers, R., 1998: Building design and the built environment. Progress in pig science 534

Gisbert, J.P.; Pajares, J.M., 2005: 13C-urea breath test in the management of Helicobacterpylori infection. The urea breath test is a noninvasive and very accurate test for the diagnosis of Helicobacter pylori infection. However, false negative urea breath test results have been reported to occur in a considerable percentage of the individuals taking pr...

Hunter, M.G.; Jacob, A.; Coggeshall, K.M.rk; Avalos, B.R., 1999: Alterations in ship recruitment contribute to hyperproliferative responses in SCN/AML. Blood 94(10 SUPPL 1 PART 1): 592a, Nov 15

Ross, A.C.tharine; Dawson, H.D.; Decicco, K.L.; Zolfaghari, R.; Li, N.Q.an, 1999: Marginal vitamin A status as a risk factor for low CD4 T cell and NK cell numbers and function, and increased NKT cells. Immunology 98(suppl 1): 75, Dec