geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Pathogenic bacterium Helicobacter pylori alters the expression profile of p53 protein isoforms and p53 response to cellular stresses


, : Pathogenic bacterium Helicobacter pylori alters the expression profile of p53 protein isoforms and p53 response to cellular stresses. Proceedings of the National Academy of Sciences of the United States of America 109(38): E2543-E2550

The p53 protein plays a central role in the prevention of tumorigenesis. Cellular stresses, such as DNA damage and aberrant oncogene activation, trigger induction of p53 that halts cellular proliferation and allows cells to be repaired. If cellular damage is beyond the capability of the repair mechanisms, p53 induces apoptosis or cell cycle arrest, preventing damaged cells from becoming cancerous. However, emerging evidence suggests that the function of p53 needs to be considered as isoform-specific. Here, we report that the expression profile of p53 can be shifted toward inhibitory p53 isoforms by the pathogenic bacterium Helicobacter pylori, which is known for its strong association with gastric cancer and gastric mucosa-associated lymphoid tissue lymphoma. We found that interaction of H. pylori with gastric epithelial cells, mediated via the cag pathogenicity island, induces N-terminally truncated Δ133p53 and Δ160p53 isoforms in human cells. Induction of an orthologous p53 isoform, Δ153p53, was also found in H. pylori-infected Mongolian gerbils. The p53 isoforms inhibit p53 and p73 activities, induce NF-κB, and increase survival of infected cells. Expression of Δ133p53, in response to H. pylori infection, is regulated by phosphorylation of c-Jun and activation of activator protein-1-dependent transcription. Together, these results provide unique insights into the regulation of p53 protein and may contribute to the understanding of tumorigenesis associated with H. pylori.

US$19.90

PMID: 22927405

DOI: 10.1073/pnas.1205664109


Other references

Ross, W.A.; Alkassab, F.; Lynch, P.M.; Ayers, G.D.; Ajani, J.; Lee, J.H.; Bismar, M., 2006: Evolving role of self-expanding metal stents in the treatment of malignant dysphagia and fistulas. Self-expanding metal stents (SEMS) are touted as the cornerstone of endoscopic palliation of unresectable esophageal cancer. However, usage at MD Anderson has fallen in recent years, despite a greater volume of patients with esophageal cancer. To...

Emerit, M.; Bonaric, J-C.; Blandin, P., 1978: Apports des caracteres trichobothriotaxiques a la connaissance systematique des araignees la famille des Pisauridae. Variation of the trichobothriotaxy in the legs of Pisauridae is studied for the 1st time. Ten African genera were studied and the patterns of trichobothriotaxy were described and compared to Dolomedes plantarius (Clerck, 1758). The trichobothriota...

Zellmer, W.A., 1991: Upgrading quality assurance for pharmacy-prepared sterile products. American Journal of Hospital Pharmacy 48(11): 2387-2388

Ortegat, P.E., 1955: A case of Looser-Milkman syndrome. Acta Physiotherapica et Rheumatologica Belgica 10(2): 75-81

Nair, R.; Tran, Q.T.; Gunning Trant, C.; Wood, R.; Gunasekera, D., 2007: Global trade liberalisation - opportunities for Australian farmers. This paper indicates that global merchandise trade liberalization will generate substantial benefits for the international community, including Australia. Two illustrative merchandise trade reform scenarios are analysed, providing insights into th...

Koponen, S., 1981: Coleophora glaucicolella (Lepidoptera, Coleophoridae) new to the fauna of Greenland. Annales entomologici fennici7(1): 28

Tiseo, P.J.; Vargas, R.; Perdomo, C.A.; Friedhoff, L.T., 1998: An evaluation of the pharmacokinetics of donepezil HCl in patients with impaired hepatic function. Aim. The aim of this study was to evaluate the pharmacokinetic profile of donepezil HCl (5 mg) in patients with impaired hepatic function, following the administration of single oral doses. Methods. This was an open-label, non-randomized study com...

Garant, D.; Sperber, E.; Moshé, S., 1992: The density of GABAB binding sites in the substantia nigra is greater in rat pups than in adults. Baclofen-displaced [3H]GABA (gamma-aminobutyric acid) binding to GABAB sites was assayed in brain regions obtained from adult and 14- to 17-day-old rats. The substantia nigra of rat pups exhibited a 3- to 5-fold higher density (Bmax) of GABAB bind...

Trasobares, A.; Pukkala, T.; Miina, J., 2004: Growth and yield model for uneven-aged mixtures of Pinus sylvestris L. and Pinus nigra Arn. in Catalonia, north-east Spain. A distance-independent diameter growth model, a static height model, an ingrowth model and a survival model for uneven-aged mixtures of Pinus sylvestris and P. nigra in Catalonia (north-east Spain) were developed. Separate models were developed fo...

Herbold, Bruce, Reviewer, 1996: Life on the edge (book review). Fisheries 21: 6