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Pathophysiology of portal hypertension, what's new?


, : Pathophysiology of portal hypertension, what's new?. Korean Journal of Gastroenterology 56(3): 129-134

Portal hypertension (PHT) is associated with changes in the intrahepatic, systemic and portosystemic collateral circulations. Alteration in vasoreactivity (vasodilation and vasoconstriction) plays a central role in the pathogenesis of PHT by contributing to increased intrahepatic resistance, hyperdynamic circulation and the expansion of the collateral circulation. PHT is also importantly characterized by changes in vascular structure; termed vascular remodeling, which is an adaptive response of the vessel wall that occurs in response to chronic changes in the environment such as shear stress. Angiogenesis, the sprouting of new blood vessels, also occurs in PHT, especially in the expansion of the portosystemic collateral circulation. These complementary processes of vasoreactivity, vascular remodeling and angiogenesis represent important targets in the research for the treatment of portal hypertension.

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PMID: 20847603


Other references

Lamas, Jé.Luiz.Tatagiba.; Arcuri, E.Apparecida.Moura.; de Brito, Cândida.Márcia.; da Cruz, K.Cristiane.Trindade., 2007: Intra-arterial versus auscultation blood pressure values as a function of cuff width. We compared intra-arterial to auscultation blood pressure values using correct (CCW) or standard (SCW) cuff widths. Intra-arterial values were obtained from the radial artery using a digital monitor. Measurements were simultaneously made by two ob...

Goor, D.A.; Edwards, J.E., 1973: The spectrum of transposition of the great arteries: with specific reference to developmental anatomy of the conus. Circulation 48(2): 406-415

Wilson, W.S., 1966: Nitrogen manuring of apple trees via root and leaf : a preliminary investigation. At 60-120 Ib/acre N, there was no difference between (NH4)2SO4 and NaNO3. Spraying with 4 % urea at 37 Ib N in the autumn, alone or in addition to solid fertilizer, showed no effects.

Nissim, F.; Ashkenazy, M.; Borenstein, R.; Czernobilsky, B., 1981: Tuberculoid cornstarch granulomas with caseous necrosis. A diagnostic challenge. We studied a patient in whom peritoneal granulomas developed with caseous-type necrosis after exposure to cornstarch from surgical gloves. This necrotizing type of lesion, which is the least common among cornstarch granulomas, can simulate tubercu...

Belmonte, Mônica.A.; Santos, M.F.; Kihara, A.H.; Yan, C.Y.I.; Hamassaki, Dânia.E., 2006: Light-Induced photoreceptor degeneration in the mouse involves activation of the small GTPase Rac1. PURPOSE. Rho GTPases play a central role in actin-based cytoskeleton reorganization, and they participate in signaling pathways that regulate gene transcription, cell cycle entry, and cell survival. This study verifies the role of Rac1 during ligh...

Tatsuno, T.; Iwaida, M.; Kawashiro, I., 1968: Hygienic chemical aspects of plastics. I. Elution test of plastic materials for food packaging and wares. Eisei Shikenjo Hokoku. Bulletin of National Institute of Hygienic Sciences 86: 124-127

Angeliev, V.N.kolova, N., 1982: Productivity of true-rooted rose. Nauchni trudove Vissh selskostopanski institut "Vasil Kolarov"7(2): 115-119

Hicks, L.L.; Koenig, S.E.; Boles, K.E.; Madsen, R.W.; Kling, B.W.; Mitchell, J.A.; Webb, W.D.; Tracy, J.A., 2000: A method for identifying comparison counties: application to a rural telemedicine evaluation project. The evaluation of telemedicine activity in rural communities is complicated by the fact that most telemedicine sites are chosen because of their existing telecommunications infrastructure and institutional relationships, not by a random selection...

Link, R.P.; Horn, J.; Joshi, H.C., 1974: Effect of isopropamide iodide on gastrointestinal motility in ruminants. Subcutaneous injection of isopropamide in lambs, ewes, young calves and one heifer resulted in a parasympatholytic effect quantitatively similar to that in man. Injection of this drug in calves with infectious diarrhoea depressed intestinal hyperm...

Jung, K.; Kühler, S.; Klotzek, S.; Becker, S.; Henke, W., 1993: Effect of storage temperature on the activity of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione S-transferase in rat liver and kidney homogenates. The behavior of the catalytic activities of the enzymes superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase and glutathione reductase was tested in rat liver and kidney homogenates stored at 4, -20 and -70 degrees C a...