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Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial


, : Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial. Journal of Clinical Oncology 28(6): 1061-1068

PURPOSE Pazopanib is an oral angiogenesis inhibitor targeting vascular endothelial growth factor receptor, platelet-derived growth factor receptor, and c-Kit. This randomized, double-blind, placebo-controlled phase III study evaluated efficacy and safety of pazopanib monotherapy in treatment-naive and cytokine-pretreated patients with advanced renal cell carcinoma (RCC). PATIENTS AND METHODS Adult patients with measurable, locally advanced, and/or metastatic RCC were randomly assigned 2:1 to receive oral pazopanib or placebo. The primary end point was progression-free survival (PFS). Secondary end points included overall survival, tumor response rate (Response Evaluation Criteria in Solid Tumors), and safety. Radiographic assessments of tumors were independently reviewed. Results Of 435 patients enrolled, 233 were treatment naive (54%) and 202 were cytokine pretreated (46%). PFS was significantly prolonged with pazopanib compared with placebo in the overall study population (median, PFS 9.2 v 4.2 months; hazard ratio [HR], 0.46; 95% CI, 0.34 to 0.62; P < .0001), the treatment-naive subpopulation (median PFS 11.1 v 2.8 months; HR, 0.40; 95% CI, 0.27 to 0.60; P < .0001), and the cytokine-pretreated subpopulation (median PFS, 7.4 v 4.2 months; HR, 0.54; 95% CI, 0.35 to 0.84; P < .001). The objective response rate was 30% with pazopanib compared with 3% with placebo (P < .001). The median duration of response was longer than 1 year. The most common adverse events were diarrhea, hypertension, hair color changes, nausea, anorexia, and vomiting. There was no evidence of clinically important differences in quality of life for pazopanib versus placebo. CONCLUSION Pazopanib demonstrated significant improvement in PFS and tumor response compared with placebo in treatment-naive and cytokine-pretreated patients with advanced and/or metastatic RCC.

US$19.90

PMID: 20100962

DOI: 10.1200/JCO.2009.23.9764


Other references

Bacskulin, J., 1963: Subconjunctival auto-blood injections in fresh and old burns. Klinische Monatsblatter für Augenheilkunde 142: 728-733

Yoshikura S.; Shibata K.; Maruyama S., 1981: Garnet-clinopyroxene amphibolite from the Kurosegawa tectonic zone, near Kochi City; petrography and K-Ar age. Ganseki Kobutsu Kosho Gakkai-Shi = Journal of the Japanese Association of Mineralogists, Petrologists and Economic Geologists 76(3): 102-109

Connors, T.A.; Farmer, P.B.; Foster, A.B.; Gilsenan, A.M.; Jarman, M.; Tisdale, M.J., 1973: Metabolism of aniline mustard (N,N-di-(2-chloroethyl)aniline). Biochemical Pharmacology 22(16): 1971-1980

Kadesjö, B.; Gillberg, C., 2000: Tourette's disorder: epidemiology and comorbidity in primary school children. Objective: To study prevalence and comorbidity of Tourette's disorder in the general population of children and in a clinical setting. Method: School-age children in the general population and children attending a county-wide tic disorder cli...

Rao, S.B.; Mallick, B.B., 1969: Pullorum-gallinarum diseases control by whole blood rapid plate test during the early age of chickens. Of 150 three-day-old chicks given an oral dose of approx. 65 hundred million Salmonella gallin arum, 52 died within 15 days. Thereupon furazolidone was fed for five days, and only six further deaths were recorded. The birds were submitted to the r...

Akramovski, M.N., 1952: Dictyocaulus in horses.. In his study of the bionomics of Dictyocaulus, Akramovski found that the larvae can climb 2 cm. to 8 cm. vertically and migrate up to 30 cm. horizontally. First and secondstage larvae die within 5 to 40 minutes during desiccation; infective larvae...

Desjardins P.R.; Drake R.J.; French J.V., 1969: Transmission of citrus ringspot virus to citrus d and non citrus hosts by dodder d campestris subinclusa d. Plant Disease Reporter 53(12): 947-948

Farmer, A.; Elkin, A.; McGuffin, P., 2006: The genetics of bipolar affective disorder. Molecular genetic studies of bipolar affective disorder are beginning to show some positive and reproducible findings. The most relevant of these will be reviewed. Obtaining consistent findings from whole genome scans has been hampered by small sa...

Iwanaga, T.; Yui, R.; Kuramoto, H.; Fujita, T., 1987: The paraneuron concept and its implications in neurobiology. Unknown

Ortiz de Zarate Rocandio, A.; Ortiz de Zarate Lopez, A., 1961: Moluscos terrestres recogidos en Ia pro vincia de Huelva. Boletin de la Sociedad Espanola de Historia Natural Biol, 59: 169-190