+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Persistent infection of rhesus monkeys with 'Helicobacter macacae' and its isolation from an animal with intestinal adenocarcinoma

, : Persistent infection of rhesus monkeys with 'Helicobacter macacae' and its isolation from an animal with intestinal adenocarcinoma. Journal of Medical Microbiology 59(Pt 8): 961-969

A novel helicobacter, 'Helicobacter macacae', was previously isolated from a colony of rhesus and cynomolgus monkeys in which diarrhoea from chronic idiopathic colitis was enzootic. A survey performed in a second colony of rhesus monkeys without a history of chronic diarrhoea determined that 57 % were faecal-culture positive for Helicobacter species. Ten years after the survey, one of the animals from which 'H. macacae' had been isolated, a 23-year-old, intact male rhesus monkey (Macaca mulatta), presented with partial inappetence and progressive weight loss. Subsequent evaluation of the monkey revealed anaemia, hypoproteinaemia, hypoalbuminaemia and a palpable abdominal mass. Contrast radiography suggested partial intestinal obstruction. The animal was euthanized and a diagnosis was made of intestinal adenocarcinoma of the ileocaecocolic junction with metastasis to regional lymph nodes and liver. Microaerobic culture of caecal tissue yielded a helicobacter organism identified as 'H. macacae' by 16S rRNA gene sequencing - the same species of bacteria isolated 10 years previously. The liver, small intestine and colon were also positive by PCR for Helicobacter species. Intestinal adenocarcinoma is the most common malignancy of aged macaques. Faeces or caecal tissue from five out of five monkeys that remained from the original cohort and that were colonized with 'H. macacae' in the initial survey were positive for the organism. The apparent persistence of 'H. macacae' in these animals, the isolation of the bacterium from animals with colitis and the recognition of the importance of inflammation in carcinogenesis raise the possibility of an aetiological role in the genesis of intestinal adenocarcinoma in aged rhesus monkeys.


PMID: 20413623

DOI: 10.1099/jmm.0.019117-0

Other references

Kulej, M., 2005: Variation of some morphological characteristics of foliage of grand fir (Abies grandis Lindl.) of different provenances growing under mountain conditions of Beskid Sadecki. The paper presents the results of studies on variation of selected morphological features of the assimilative apparatus of grand fir (Abies grandis Lindl.) of 7 partial populations tested under mountain conditions of Beskid Sadecki. Variability of...

Liu, Z.; Koyi, H.A., 2013: The impact of a weak horizon on kinematics and internal deformation of a failure mass using discrete element method. Weak horizons within slopes may induce and/or accelerate failure of slopes. In this study, we focus on the effect of orientation, location and dimension of a weak horizon on the mode and kinematics of downslope movement of a failure mass using dis...

Ilmberger, J., 1984: Dissociation of visual and auditory order thresholds after cerebral injury in man. Visual and auditory order thresholds were measured with aphasic patients suffering from lesions of the left hemisphere, non-aphasic patients with lesions of the right hemisphere, and a control-group of normals. The aphasic patients showed the high...

O'Haga, C.; Borthwick, R.E., 2016: Land-based Warm-up Is Inferior To Water-based Warm-up For 100m Freestyle Swimming Performance: 3292 Board #357 June 3, 3: 30 PM - 5: 00 PM. Medicine and Science in Sports and Exercise 48(5 Suppl 1): 944-944

Gomez, V.; Gomez, C.; Gomez, G.; Greeley, G.H.Jr, 1999: Preferential activation of bax gene expression during acute pancreatitis. Gastroenterology 116(4 PART 2): A1128, April

Crocetti, E.; Buiatti, E.; Amorosi, A., 1995: Prostate cancer: population-based survival rates in central Italy. Aims: To evaluate survival in prostate cancer patients in the Province of Florence where the Tuscany Cancer Registry is active. Methods: The survival of 777 patients with prostate cancer diagnosed in the period 1985-87 was evaluated. The observed...

Sola, C.Ralph De, 1930: The Liebespiel of Tes-tudo vandenburghi, a new name for the Mid -Albemarle Island Galapagos tortoise. Description of the mating of T. vandenburghi (p. 79), based upon Testudo sp. of Van Denburgh. The roaring of mating d1cf may be heard at 400-500 yds.

Mutneja, P.; Dhawan, P.; Raina, A.; Sharma, G., 2012: Menopause and the oral cavity. Menopause is associated with a large number of symptoms ranging from physical to psychological. These symptoms may unfavorably affect oral health and treatment needs requiring dentists to be aware of the symptoms and health care needs of peri-meno...

Fan, Weiqiao, 2012: An experimental comparison of the flexibility in the use of thinking styles in traditional and hypermedia learning environments. The objective of the instructional experiment was to examine if the use of thinking styles is flexible in traditional and hypermedia learning environments, and if a hypermedia learning environment possesses obvious advantages than a traditional en...

Mcgugan A.; Strimple H.L., 1980: Pelecocrinus sp compare pelecocrinus banffensis from the banff formation lower mississippian kananaskis valley alberta canada. A new occurrence of Pelecocrinus cf. P. banffensis is described from the Banff Formation of Osage age, Kananaskis Valley, Alberta.