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Pharmacoresistant epilepsy: unmet needs in solving the puzzle(s)

, : Pharmacoresistant epilepsy: unmet needs in solving the puzzle(s). Epilepsia 54 Suppl 2: 80-85

Pharmacoresistant epilepsy is a significant medical problem. The 2nd Halifax International Epilepsy Conference & Retreat identified crucial needs, which if successfully addressed, will aid in paving the way to improved lives for people with pharmacoresistant epilepsy. These are needs: (1) for an evidence-based and dynamic definition of pharmacoresistant epilepsy; (2) for a comprehensive description of the natural history of pharmacoresistant epilepsy; (3) for a comprehensive description of the complications and comorbidities of pharmacoresistant epilepsy; (4) for a rigorous delineation of the epidemiology and socioeconomic impact of pharmacoresistant epilepsy; (5) for clinically meaningful diagnostic and prognostic physiologically based electroencephalography (EEG) biomarkers; (6) for clinically meaningful diagnostic and prognostic anatomically based (MRI Imaging) biomarkers; (7) for biomolecular/biochemical mechanistic understanding of etiopathogenesis for pharmacoresistant epilepsy; (8) for representative animal models of pharmacoresistant epilepsy; (9) for new and effective drugs or other novel treatments for pharmacoresistant epilepsy; and (10) to promote continuing research and research funding targeting pharmacoresistant epilepsy.


PMID: 23646978

DOI: 10.1111/epi.12191

Other references

Shu, D-g., 1986: Notes on the oldest fossil bivalves from the Niutitang Formation of Fuquan, Guizhou. Acta Palaeontologica Sinica, 252: 219-222

Kauffman H.F.; Koeter G.H.; Van Der Heide S.; D.M.nchy J.G.R.; Kloprogge E.; D.V.ies K., 1989: Cellular and humoral observations in a patient with allergic bronchopulmonary aspergillosis during a nonasthmatic exacerbation. A patient is described with an asymptomatic exacerbation of allergic bronchopulmonary aspergillosis (ABPA), clinically characterized by pulmonary infiltrates, with absence of obstructive reactions and a short period of hemoptysis 2 weeks before ho...

Martins H.C.; Noronha F., 1991: Geochemsitry and petrology of post-tectonic biotitic granitoids of the Vila Pouca de Aguiar region. Geociencias (Aveiro) 6(1-2): 1-15

Yan, P.; Xu, H., 2002: Influence of EM Bokashi, on nodulation, physiological characters and yield of peanut in nature farming fields. Effects of EM bokashi organic fertilizer on nodulation, physiological properties and yield of peanut plants were investigated in a nature-farming field. Compared to chemical fertilizer, EM bokashi fertilizer significantly increased both the nodule...

Michejda J.; Hryniewiecka L.; Domka Popek A., 1982: Energetic competence of the alternative respiratory pathway in the amoeba acanthamoeba castellanii. Biology of the Cell (Paris) 45(2): 223

Kulamowicz, I.; Oliński, R.; Walter, Z., 1984: The influence of cysteine on the reaction of d-guanosine with cis-diamminedichloroplatinum (II). Mono- and bifunctional complexes of cis DDP and d-guanosine were isolated on Sephadex G-25. The presence of cysteine in incubation mixture resulted in the vanishing of bifunctional complex of d-guanosine and the appearance of d-guanosine-cis DDP-c...

Van Berg, C., 1952: The dangers of increasing sal-inationto agriculture and horticulture. Salination of underground water by supplies from main water courses and ditches may lower the yields of arable, pastoral and horticultural crops. The rate of salination is closely related to the perviousness of the soil, the elevation of the face...

Derbyshire, E.J.; Wawrzynczak, E.J., 1992: An anti-mucin immunotoxin BrE-3-ricin A-chain is potently and selectively toxic to human small-cell lung cancer. Monoclonal antibodies (MAbs) known to recognize epithelial mucin or defined carbohydrate structures present on mucin molecules were screened for their ability to form cytotoxic agents with ricin A-chain active against human small-cell lung cancer...

Chen, W.; Xu, Z.; Mu, J.; He, B.; Yang, L.; Lin, L.; Meng, S.; Mu, F.; Gan, H.; Huang, S.; Wen, J.; Fang, J.; Wang, J., 2005: Real-time quantitative fluorescent reverse transcriptase-PCR for detection of severe acute respiratory syndrome-associated coronavirus RNA. SARS-associated coronavirus (SARS-CoV) has been confirmed as the pathogen for severe acute respiratory syndrome (SARS). The aim of our study was to construct a sensitive and specific real-time quantitative fluorescent (QF) reverse transcriptase (R...

Fendt, L.; Röck, A.; Zimmermann, B.; Bodner, M.; Thye, T.; Tschentscher, F.; Owusu-Dabo, E.; Göbel, T.M.K.; Schneider, P.M.; Parson, W., 2012: MtDNA diversity of Ghana: a forensic and phylogeographic view. West Africa is characterized by a migration history spanning more than 150,000 years. Climate changes but also political circumstances were responsible for several early but also recent population movements that shaped the West African mitochondri...