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Phase 2 trial of carboplatin, weekly paclitaxel, and biweekly bevacizumab in patients with unresectable stage IV melanoma: a North Central Cancer Treatment Group study, N047A


, : Phase 2 trial of carboplatin, weekly paclitaxel, and biweekly bevacizumab in patients with unresectable stage IV melanoma: a North Central Cancer Treatment Group study, N047A. Cancer 115(1): 119-127

Vascular endothelial growth factor (VEGF) plays an important role in the growth and metastatic progression of melanoma. Exposure of melanoma cells to chemotherapy induces VEGF overproduction, which in turn may allow melanoma cells to evade cell death and become chemotherapy resistant. Therefore, in patients with metastatic melanoma, the combination of chemotherapy with an agent that specifically targets VEGF might be able to control tumor growth and progression more effectively than chemotherapy alone. A 2-stage phase 2 clinical trial was conducted in patients with unresectable stage IV (metastatic) melanoma to assess antitumor activity and the toxicity profile of the combination of carboplatin (area under the curve 6 iv on Day 1 of a 28-day cycle), paclitaxel (80 mg/m2 iv on Days 1, 8, and 15), and bevacizumab (10 mg/kg iv on Days 1 and 15). Treatment was continued until progression or intolerable toxicity. Fifty-three patients (62.3% male) were enrolled. Nine (17%) patients achieved partial remission, and another 30 (57%) achieved stable disease for at least 8 weeks. Median progression-free survival and median overall survival were 6 months and 12 months, respectively. One patient died after 8 treatment cycles from intracranial hemorrhage into undiagnosed brain metastases. The most common severe (grade>or=3) toxicities were neutropenia (53%), thrombocytopenia (11%), hypertension (9%), and anemia (8%). This combination of carboplatin, paclitaxel, and bevacizumab appears to be moderately well tolerated and clinically beneficial in patients with metastatic melanoma. Further study of this combination is warranted.

US$19.90

PMID: 19090009

DOI: 10.1002/cncr.23987


Other references

Eames, Jonathan., 1998: Treasures of Vietnam. World Birdwatch. September; 203: 8-11

Arnaoudova, V., 1976: Treatment and prevention of acute respiratory virus infections in children with leukocytic interferon. Children with respiratory virus infections and healthy contacts were given leukocytic interferon (LIF) as treatment and prophylaxis. The results emphasize the effectiveness of the treatment when LIF was given on the 1st or 2nd day after onset of i...

Chalaia, L.E., 1959: Donnees sur lepidemiologie des trichomoniase chez lhomme. Unknown

Law, F., 1971: Open-angle glaucoma presenting as conjunctivitis. Proceedings of the Royal Society of Medicine 64(9): 935-936

Thompson, RT., 1993: Report on the weevil collection of the B.P. Bishop Museum, Honolulu. Curculio, 6-7 No. 34

Kendall, A.B.; Scott, P.A.; Karlsen, K.A., 2012: The S.T.A.B.L.E.® Program: the evidence behind the 2012 update. First released in 1996, the S.T.A.B.L.E.® Program has provided evidence-based education in the postresuscitation and pretransport stabilization care of sick newborns to more than a quarter million multidisciplinary perinatal healthcare team membe...

Fernandez-Torrente, I.; Monturet, S.; Franke, K.J.; Fraxedas, J.; Lorente, N.; Pascual, J.I., 2007: Long-range repulsive interaction between molecules on a metal surface induced by charge transfer. The adsorption of a molecular electron donor on Au(111) is characterized by the spontaneous formation of a superlattice of monomers spaced several nanometers apart. The coverage-dependent molecular pair distributions obtained from scanning tunneli...

Lim, K.I.; Butt, K.; Naud, K.; Smithies, M., 2017: Amniotic Fluid: Technical Update on Physiology and Measurement. OUTCOMES: EVIDENCE: A MEDLINE and KFINDER search was used to identify relevant articles, with review of bibliography identified article including Cochrane reviews and recent review articles. The evidence collected was reviewed by the Diagnostic Im...

Beach, A.C.; Agrawal, S.C.; Lambert, G.R.; Nesnow, S.; Gupta, R.C., 1993: Cyclopenta pyrene-3,4-epoxide DNA adducts in vitro Similarity to cyclopenta pyrene DNA adducts induced in the rat. Proceedings of the American Association for Cancer Research Annual Meeting 34(0): 159

Fleckenstein, L., 1996: Calif. doc aims to take firm nationwide. Modern Healthcare 26(18): 88, 90-88, 90