+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Phase I/II prospective trial of autologous platelet tissue graft in gynecologic surgery

, : Phase I/II prospective trial of autologous platelet tissue graft in gynecologic surgery. Journal of Minimally Invasive Gynecology 14(5): 633-637

To perform the original phase I/II trial of autologous platelet tissue graft in gynecologic surgery to evaluate toxicity and efficacy on decreasing pain. Prospective nonrandomized trial (Canadian Task Force classification II-A). Teaching hospital. Fifty-five consecutive patients undergoing major gynecologic surgery were entered into this prospective phase I/II trial and were matched with 55 patients from the previous 6 months. After anesthesia was induced, peripheral venous blood (55 mL) was obtained from the patient producing, autologous platelet tissue graft (20 mL). At completion of surgery, autologous platelet tissue graft was directly applied to the surgical site. Median pain on the day of surgery was 2.7 (mild) in the autologous platelet tissue graft group vs 6.7 (severe) in the control group, p <.001. Likewise, pain on postoperative day 1 was 2.1 (mild) in the autologous platelet tissue graft group vs 5.5 (moderate) in the control group, p < or =.001. Median of morphine per hospital stay for the autologous platelet tissue graft group was 17 mg (range 1-98 mg) vs 26 mg (range 3-90 mg) in the control group, which was statistically significant at p = .02. There were no adverse effects associated with autologous platelet tissue graft. In the original phase I/II prospective trial of autologous platelet tissue graft in gynecologic surgery, there were no apparent adverse effects, and pain was significantly reduced.


PMID: 17848327

DOI: 10.1016/j.jmig.2007.05.014

Other references

Weng, H-Xin.; Weng, J-Ke.; Yong, W-Bin.; Sun, X-Wu.; Zhong, H., 2003: Capacity and degree of iodine absorbed and enriched by vegetable from soil. To understand the biogeochemical transfer of iodine from the soil to plants, the absorbability and bioaccumulation of iodine in plants were examined in a pot experiment using radish, spinach and Chinese cabbage as test plants. Iodine fertilizer, c...

Brown, W.R., 1953: The determination of hemoglobin in the clinical laboratory. Guthrie Clinic Bulletin 23(1): 38-41

Puchelle, E.; Girard, F.; Zahm, J.M., 1976: Rheology of bronchial secretions and mucociliary transport. Optimal relationships between mucociliary clearance and rheological properties of bronchial secretions expectorated by patients with chronic bronchitis have been analysed by successive measurements of visco-elasticity with a rotational rheometer a...

Anonymous, 1970: International nomenclature of constitutional diseases of bones. Annales de Radiologie 13(7): 455-464

Smith, Esc, 1980: Zophiuma lobulata Ghauri (Homoptera: Lophopidae) and its relation to the Finschhafen coconut disorder in Papua New Guinea Ooencyrtus malayensis as predator, natural control. Papua New Guinea agricultural journal 31(1-4): 37-45

Howard, R.B., 1981: Computed tomography--a paean. Postgraduate Medicine 69(3): 27-28

Anonymous, 1993: Antiepileptic Drugs in Psychiatry. Proceedings of an international symposium. Freiburg, Federal Republic of Germany, January 29-30, 1993. Neuropsychobiology 27(3): 121-192

Jung,; Joo, Y.H.e; Lim, J.H.un; Woo, K.D.e; Kim, D.S.o, 1993: Studies on the development of purification plant of piggery wastewater with the modified anaerobic digestion process. RDA Journal of Agricultural Science Soil & Fertilizer 35(1): 301-307

Anonymous, 1987: HBV and glomerulonephritis. Lancet 2(8553): 252-253

M.S.T.B.kowinski; Raymond Jeanloz, 1980: High pressure metallization of CaO; tentative evidence. Geophysical Research Letters 7(4): 227