+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Phase II trial of temozolomide (TMZ) plus irinotecan (CPT-11) in adults with newly diagnosed glioblastoma multiforme before radiotherapy

, : Phase II trial of temozolomide (TMZ) plus irinotecan (CPT-11) in adults with newly diagnosed glioblastoma multiforme before radiotherapy. Journal of Neuro-Oncology 95(3): 393-400

This phase II trial evaluated efficacy and safety of temozolomide (TMZ) in combination with irinotecan (CPT-11) before radiotherapy in patients with newly diagnosed glioblastoma multiforme (GBM). Prior to radiotherapy, patients were treated with a maximum of three 6-week cycles of TMZ and CPT-11. Patients received TMZ at a dose of 200 mg/m(2)/day on days 1-5 and CPT-11 on days 1, 8, 22, and 29, with a dose adjustment for enzyme-inducing antiepileptic drug use. The primary end point was objective response rate (ORR). Secondary end points included progression-free survival (PFS), overall survival (OS), safety, and tumor O(6)-methylguanine-DNA methyltransferase (MGMT) expression. Of the 42 patients treated, 8 (19%) patients achieved a partial response. Median PFS and median OS were 3.1 and 13.8 months, respectively. Grade 3 or 4 AEs were documented in 36% of patients, most of which were hematologic (29%). Twenty-four percent of patients had grade 3 or 4 non-hematologic AEs, with gastrointestinal AEs being the most common (12%) Two patients died, one of intracranial hemorrhage and one of treatment-related renal failure. Low MGMT expression, compared with high MGMT expression, showed no significant difference in ORR (25 vs. 8%), median PFS (14 vs. 5 months) or OS (21 vs. 15 months). Although TMZ plus CPT-11 is at least comparable in efficacy to TMZ alone, this combination appears more toxic and poorly tolerated. The lack of correlation of activity with MGMT expression is intriguing, but needs further evaluation in subsequent trials.


PMID: 19533023

DOI: 10.1007/s11060-009-9937-x

Other references

Thornley M.J.; Andrews M.G.; Briggs J.O.; Leigh B.K., 1979: Inhibitors in human urine of radio immunoassay for the detection of gonococcal antigens. Several substances in urine inhibited the radioimmunoassay of added gonococcal antigens [Ag]. The supernatants of 2/3 of urine samples from male patients with gonorrhea or non-specific urethritis (NSU) were inhibitory. The inhibitory caused by man...

Lopez, J.A.; Li, C.Q.; Weisman, S.; Chambers, M.; Dong, J.F.i, 1995: Expression of the platelet GP Ib-IX complex in heterologous cells induces shape change and increases actin-binding protein synthesis. Journal of Cellular Biochemistry Supplement 0(19B): 137

Zelnio, R.N.; Cisneros, R.M.; Owen, J.W., 1981: Diabetic urine testing in South Carolina. Drug Intelligence & Clinical Pharmacy 15(4): 292-4, 309

Do#an, S.-; Turan, P#lnar-; Do#an, M.-; Arslan, O.-; Alkan, M., 2007: Partial characterization of peroxidase from the leaves of thymbra plant (Thymbra spicata L. var. spicata). Peroxidase (EC; donor: hydrogen-peroxide oxidoreductase) catalyses the oxidation of various electron donor substrates (e.g. phenols, aromatic amines). In this study, the peroxidase was extracted from Thymbra spicata L. var. spicata and,...

Silva, Sély.V.; Lima, Míra.A.; Cella, N.; Jaeger, R.G.; Freitas, V.M., 2016: ADAMTS-1 Is Found in the Nuclei of Normal and Tumoral Breast Cells. NlmCategory="UNASSIGNED">Proteins secreted in the extracellular matrix microenvironment (ECM) by tumor cells are involved in cell adhesion, motility, intercellular communication and invasion. The tumor microenvironment is expansively...

Lambe, D., 1990: Idiopathic interstitial fibrosis. The lung has only a limited pattern of response to injury. Idiopathic interstitial fibrosis is a descriptive term, describing the end stage of one pattern of pulmonary fibrosis in which the inflammation lies within the structure of the alveolar wa...

Wang Kun, 1991: Glassy silicate microspherules from an Upper Devonian sediment; microtektites?. Abstracts with Programs Geological Society of America: , Pages 277. 1991.

Bahlburg H.; Baeumer M.; Kappel J.; Teichert B., 2001: Provenance analysis of Silurian to Carboniferous siliciclastic formations, Pisuerga-Carrion Nappe, Cantabrian Mountains, Spain. Schriftenreihe der Deutschen Geologischen Gesellschaft 13: 18

Popov, K.P., 1974: Are the Pistacia vera communities of Central Asia a forest vegetation type?. A floristic analysis of the P. vera communities that occur in the south of Soviet Central Asia as the final stage in the degradation of woody vegetation [cf. FA 35, 2801, 2875; 36 3885, 5377]. It is concluded that they should properly be classifie...

Kamphorst, T.J.; Beek, A. van, 1985: Cultural participation in the Netherlands. Facts and figures, taken from the general data of several national surveys and extended with data from other publications present a picture of cultural participation in the Netherlands. Explanations for the differences in participation are outline...