+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Phylogenetic analysis of dysbiosis in ulcerative colitis during remission

, : Phylogenetic analysis of dysbiosis in ulcerative colitis during remission. Inflammatory Bowel Diseases 19(3): 481-488

Presence of intestinal microbes is a prerequisite for the development of ulcerative colitis (UC), although deviation of the normal intestinal microbiota composition, dysbiosis, is presumably implicated in the etiology of UC. The fecal microbiota of 30 UC samples obtained from 15 patients who were sampled twice and from 15 healthy control subjects originating from 2 geographic locations was analyzed using highly reproducible phylogenetic microarray that has the capacity for detection and quantification of more than 1000 intestinal bacteria in a wide dynamic range. The fecal microbiota composition is not significantly influenced by geographic location, age, or gender, but it differs significantly between the patients with UC and the control subjects (P = 0.0004). UC-associated microbiota is stable during remission and similar among all patients with UC. Significant reduction of bacterial diversity of members of the Clostridium cluster IV and significant reduction in the abundance of bacteria involved in butyrate and propionate metabolism, including Ruminococcus bromii et rel. Eubacterium rectale et rel., Roseburia sp., and Akkermansia sp. are markers of dysbiosis in UC. Increased abundance of (opportunistic) pathogens including Fusobacterium sp., Peptostreptococcus sp., Helicobacter sp., and Campylobacter sp. as well as Clostridium difficile were found to be associated with UC. Dysbiosis in UC is stable in time and shared between patients from different geographic locations. The microbial alterations offer a mechanistic insight into the pathogenesis of the disease.


PMID: 23385241

DOI: 10.1097/MIB.0b013e31827fec6d

Other references

Kuleshova, E.; Ryabova, N.V., 1989: The effect of iron deficiency in the body on mental performance of women engaged in intellectual activities. It is concluded that in women iron deficiency results in reduced intellectual performance and increased fatigue.

Fimland, E.A., 1976: Estimation of sire's breeding value. VI. Different linear prediction methods discussed in the context of the breeding structure of the population. C.R. Henderson's method of sire evaluation [see ABA 44, 1041], and its applicability to Norwegian conditions, is discussed. Some of the results obtained by Fimland in earlier issues of this journal are also discussed.

Auriol, J.; Chevrier, D.; Guesdon, J.L., 1997: Acetoxy-acetylaminofluorene-modified dGTP can be used to label oligonucleotides or DNA enzymatically. A competitive enzyme immunoassay using a bispecific monoclonal antibody (Bi-MAb) was developed to quantify acetylaminofluorene (AAF) adducts fixed on DNA and then compared to the spectrophotometric method. It was shown that this simple method allo...

Ko, S-Fat.; Liang, C-Di.; Yip, H-Kan.; Huang, C-Cheng.; Ng, S-Hang.; Huang, C-Fu.; Chen, M-Chi., 2010: Amplatzer septal occluder closure of atrial septal defect: evaluation of transthoracic echocardiography, cardiac CT, and transesophageal echocardiography. The purpose of this study was to compare transthoracic echocardiography (TTE), cardiac CT, and transesophageal echocardiography (TEE) in the evaluation of secundum atrial septal defect (ASD) for closure with an Amplatzer septal occluder in pediatr...

Lang, Bruno ., 1998: Papers from the Normandy Ornithology Convention The English Channel and its birds Caen, 5th-6th April 1997 Actes du premier colloque normand dornithologie La mer del la Manche et ses oiseaux Caen, 5-6 avril 1997. Cormoran. Avril; 103: 109-228 No 47

Van Gestel, A.J.R.; Kohler, M.; Steier, Jörg.; Teschler, S.; Russi, E.W.; Teschler, H., 2011: Cardiac autonomic dysfunction and health-related quality of life in patients with chronic obstructive pulmonary disease. At a GlanceThis study demonstrates that there is an association between cardiac autonomic dysfunction and impaired health-related quality of life in chronic obstructive pulmonary disease (COPD). The results of the present study underline the impor...

Sohn I.G., 1994: Video recording as a teaching and research tool. Abstracts with Programs - Geological Society of America 26(7): 86

Sima, P.; Bilej, M.; Slipka, J., 1995: Perienteral chloragogen tissue and its role in defense in lumbricid worms. Advances in Experimental Medicine and Biology 371a: 327-329

Sekine, O.; Ogima, I., 1971: Clinico-pathological diagnosis of respiratory infections: changing patterns of pathogens. 1. Bacteria and fungi. Rinsho Byori. Japanese Journal of Clinical Pathology 19(4): 235-241

Andreu, A.C.; Diaz-Paniagua, C.; Keller, C., 2000: The spur-thighed tortoise Testudo graeca L in Donana La tortuga mora Testudo graeca L en Donana. Monografias de Herpetologia, 5: 1-70