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Plasma biomarkers distinguish non-small cell lung cancer from asthma and differ in men and women

, : Plasma biomarkers distinguish non-small cell lung cancer from asthma and differ in men and women. Cancer Genomics & Proteomics 9(1): 27-35

Lung cancer (LC) is the leading cause of deaths caused by cancer worldwide. A diagnostic test for LC is needed for monitoring high-risk populations. Fifty-seven markers were measured using multiplex immunoassays of plasma of patients with non-small cell lung cancer (NSCLC); (245 men, 114 women, 1 unknown), asthma (67 men, 111 women, 2 unknown) and of healthy controls (165 men, 122 women, 1 unknown). Mass spectrometry was used for biomarker discovery. A support vector machine (SVM) was used for data analysis. When all biomarkers and both genders were co-analyzed, SVM classified NSCLC and asthma with an accuracy of 0.94. Restricting to NSCLC versus healthy using best subsets of variables (males: epidermal growth factor (EGF), interleukin-8 (IL-8), soluble Fas (sFas), matrix metalloproteinase-9 (MMP-9), plasminogen activator inhibitor-1 (PAI-1); females: EGF, soluble cluster of differentiation 40 (sCD40) ligand, IL-8) yielded sensitivity and specificity of 1. Expression of eleven mass spectrometric biomarkers differed between pathologies. Significant inter-pathology and gender differences between biomarkers may improve diagnosis of LC.


PMID: 22210046

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Lichy, G.; Braun, Jörg., 2016: Transfer of critically ill patients between hospitals - fundamentals and requirements. NlmCategory="UNASSIGNED">Due to the increasingly changed clinical landscape, which leads to a reduction of clinical facilities in rural regions. This also leads to a centralized clinical care, in addition to limited care options in th...

Hutla, P.; Has, S.; Cistinova, I.R.; Jelinek, O., 1988: The influence of several high-pressure discharge sources of light on the optical properties of the leaves of cabbage root seedlings. High pressure discharge light sources were used for supplementary lighting of greenhouse grown cabbage seedlings. Reflection coeff. of the leaves was measured. Optical properties of leaves were found to be dependent on the spectral structure of th...

Jeannel, R., 1920: Etude sur le Trechus fulrus Dej. Sa phylogenie, son interet biogeographique. Trabajos del Museo Ciencias Naturales Madrid Ser Zoologica, 41 1-24

Ricci, B.; Calogero, G.; Caprilli, A.; Quaranta-Leoni, F.M., 1991: Reduced severity of oxygen-induced retinopathy in the newborn rat after topical administration of timolol maleate. A preliminary study. The effects of timolol maleate on intraocular pressure (IOP) and the severity of retinopathy induced by exposure to 80% oxygen were studied in newborn Wistar rats. One drop of timolol maleate (0.25%) instilled in each eye twice a day for the first...

Marcos, A.; Estaban, M.A.; Fernandez Salguero, J., 1979: Water activity and pH of Manchego cheese. 15 samples of commercial ripened Manchego cheese were examined for their water activity (aw) and pH values. Mean values and s.d. were aw 0.95 plus or minus 0.02 and pH 5.27 plus or minus 0.14. The importance of both values is discussed in relation...

Ozawa, H.; Ikezawa, K., 1967: Studies on muscle relaxants and their antagonists. VII. The supplements on the mode of action of hexylguanidine as a skeletal muscle relaxant. Yakugaku Zasshi 87(4): 461-463

Goulding, M.; Carvalho, ML., 1984: Ecology of Amazonian needlefishes (Belonidae). Revista Brasileira de Zoologia, 23: 99-111

Reyes, O.; Gottesman, M.; Adhya, S., 1976: Suppression of polarity of insertion mutations in the gal operon and N mutations in bacteriophage lambda. Bacterial mutations (psuA and psu) known for their ability to suppress the polarity on nonsense mutations are shown to suppress the polarity of certain insertion mutations in the gal operon. The short insertion, IS1 (800 nucleotide pairs), is abou...

Yang; Bartynski; Vanderbilt, 1994: Unoccupied electronic structure of Al(111). Physical Review. B, Condensed Matter 50(16): 12025-12032

Banerjee, R.; Grunberger, D., 1986: Enhanced expression of the bacterial chloramphenicol acetyltransferase gene in mouse cells cotransfected with synthetic polynucleotides able to form Z-DNA. Recent studies have demonstrated that the left-handed, Z-DNA conformation is favored in polymers containing alternating purine/pyrimidine sequences that can exist in vivo and may play a role in gene expression. On the basis of this assumption, we...