geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Plasma phospholipid transfer activity is essential for increased atherogenesis in PLTP transgenic mice: a mutation-inactivation study


, : Plasma phospholipid transfer activity is essential for increased atherogenesis in PLTP transgenic mice: a mutation-inactivation study. Journal of Lipid Research 49(12): 2504-2512

Plasma phospholipid transfer protein (PLTP) interacts with HDL particles and facilitates the transfer of phospholipids from triglyceride (TG)-rich lipoproteins to HDL. Overexpressing human PLTP in mice increases the susceptibility to atherosclerosis. In human plasma, high-active and low-active forms of PLTP exist. To elucidate the contribution of phospholipid transfer activity to changes in lipoprotein metabolism and atherogenesis, we developed mice expressing mutant PLTP, still able to associate with HDL but lacking phospholipid transfer activity. In mice heterozygous for the LDL receptor, effects of the mutant and normal human PLTP transgene (mutPLTP tg and PLTP tg, respectively) were compared. In PLTP tg mice, plasma PLTP activity was increased 2.9-fold, resulting in markedly reduced HDL lipid levels. In contrast, in mutPLTP tg mice, lipid levels were not different from controls. Furthermore, hepatic VLDL-TG secretion was stimulated in PLTP tg mice, but not in mutPLTP tg mice. When mice were fed a cholesterol-enriched diet, atherosclerotic lesion size in PLTP tg mice was increased more than 2-fold compared with control mice, whereas in mutPLTP tg mice, there was no change. Our findings demonstrate that PLTP transfer activity is essential for the development of atherosclerosis in PLTP transgenic mice, identifying PLTP activity as a possible target to prevent atherogenesis, independent of plasma PLTP concentration.

US$19.90

PMID: 18711210

DOI: 10.1194/jlr.M800080-JLR200


Other references

Anit, S.Hgal, M.Naksh, S.Thi, H.Lenarasipu, Y.M.Ha.R.M, 2009: Development of the floral shoot and pre-anthesis cleistogamy in Hydrobryopsis sessilis Podostemaceae. Botanical Journal of the Linnean Society 159(2): 222-236

Guinamard, R.; Teulon, J., 1999: A non-selective cation channel in the apical membrane of the cortical thick ascending limb of the mouse. Journal of Physiology (Cambridge) 517P: 69P, May

Kaiser, W.; Priebe, S., 1998: Measurement of change in the subjective quality of life in chronic schizophrenia patients. Subjective quality of life in a group of chronic schizophrenia outpatients was assessed within 11/2 years (n = 50) and 4-6 weeks (n = 47) using the Berliner Lebensqualitatsprofil (German version of the Lancashire Quality of Life Profile). There ha...

Michurin, B.; Onishchenko, V., 1975: Relation between adduced capillary-sorption moisture pressure, soil moisture and film thickness. Nauchno tekhnicheskoi biulleten' po agronomicheskoi fizike: 3) 8-12

Habib, G.B.; Zoghbi, W.A.; Mann, D.L., 1994: Is diastolic function altered in normotensive subjects with a hypertensive response to exercise?. Clinical Research 42(2): 337A

Hillestad R.J., 1968: Inst computer modeling of the human systemic arterial tree. Journal Of Biomechanics: 341-353

Heiss, W.D.; Heilig, P.; Hoyer, J., 1967: Retinal impulse activity and the electroretinogram under the effect of desipramine. Experientia 23(9): 728-729

de Carvalho Buchmann Francisco Seguiguch; Seeliger Marcos; Zanella Leticia R.C.; Madureira Lauro S.P.; Tomazelli Luiz Jose; Calliari Lauro Julio, 2001: Bathymetric and sedimentologic analysis of Parcel do Carpinteiro outcrop, a lineament of submerged Pleistocene beaches off the present shoreline, Rio Grande do Sul, Brazil. The "Parcel do Carpinteiro" outcrop is a Pleistocene relict nearshore shoal located at the modern shoreface of Rio Grande do Sul, Brazil. The present work describes the results of the integration of high resolution bathymetry, 3.5 kHz ec...

Minder, Leo, 1943: Neuere Beobachtungen iiber Mikro-organismen als Schadlinge im Wasserwerksbetrieb. The author discusses the damages caused by the iron bacterium Leptothrix ochracea, and particularly by Gallionella jerruginea, which forms the so-called rust nodules (Rostknollen), rust-warts (Rostwarzen), and rust-incrustations (Rostrasen) in wat...

Pucciarelli, H.M.; Orden, A.B.; Cesani, M.F.; Oyhenart, E.E.; Mune, M.C.; Zucchi, M., 2001: Relative food intake of rats submitted to a moderate transgenerational undernutrition. An experiment on rat undernutrition through 7 generations was performed to determine whether the nutritional stress on growth increases from one generation to the next, and if an equilibrium point (AFP) in which the RFI (the amount of food intake...