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Plasmodium falciparum accompanied the human expansion out of Africa


, : Plasmodium falciparum accompanied the human expansion out of Africa. Current Biology 20(14): 1283-1289

Plasmodium falciparum is distributed throughout the tropics and is responsible for an estimated 230 million cases of malaria every year, with a further 1.4 billion people at risk of infection. Little is known about the genetic makeup of P. falciparum populations, despite variation in genetic diversity being a key factor in morbidity, mortality, and the success of malaria control initiatives. Here we analyze a worldwide sample of 519 P. falciparum isolates sequenced for two housekeeping genes (63 single nucleotide polymorphisms from around 5000 nucleotides per isolate). We observe a strong negative correlation between within-population genetic diversity and geographic distance from sub-Saharan Africa (R(2) = 0.95) over Africa, Asia, and Oceania. In contrast, regional variation in transmission intensity seems to have had a negligible impact on the distribution of genetic diversity. The striking geographic patterns of isolation by distance observed in P. falciparum mirror the ones previously documented in humans and point to a joint sub-Saharan African origin between the parasite and its host. Age estimates for the expansion of P. falciparum further support that anatomically modern humans were infected prior to their exit out of Africa and carried the parasite along during their colonization of the world.

US$19.90

PMID: 20656209

DOI: 10.1016/j.cub.2010.05.053


Other references

Ahromrit, A.L.dward, D.; Niranjan, K., 2007: Kinetics of high pressure facilitated starch gelatinisation in Thai glutinous rice. The combined effect of pressure and temperature on the rate of gelatinisation of starch present in Thai glutinous rice was investigated. Pressure was found to initiate gelatinisation when its value exceeded 200 MPa at ambient temperature. On the o...

Schwartz, D.P.; Bright, R.S., 1974: A column procedure for the esterification of organic acids with diazomethane at the microgram level. Analytical Biochemistry 61(1): 271-274

Pechova, J.; Kopecky, J.; Salat, J., 2004: Effect of tick salivary gland extract on the cytokine production by mouse epidermal cells. Previous studies have demonstrated that both tick saliva and Borrelia burgdorferi sensu lato antigens modulate the cytokine response of the host. In this paper, the effect of salivary gland extract (SGE) from Ixodes ricinus (L., 1758) ticks on cyt...

Kawamura, M.; Sakaguchi, T.; Yoshikawa, Y.; Sawa, Y., 2012: A case of mobile and massive calcifications in the left ventricle with unknown etiology. We report a case of mobile and massive calcification in the left ventricle of unknown etiology. The pathophysiology and management of this unique condition is described.

Forni C., 1982: Realization of a new multi fiber electrochemical device allowing continuous in vivo measurements of neuro mediators. The realization of a rigid C multifiber electrode is described. This polarographic electrode allows electrochemical measurements of various animal neuromediators in vitro and in vivo, with a better sensibility than previous C microelectrodes.

Feng, L.; Perepelov, A., V.; Zhao, G.; Shevelev, S., D.; Wang, O.; Senchenkova, S.'ya, N.; Shashkov, A., S.; Geng, Y.; Reeves, P., R.; Knirel, Y., A.; Wang, L., 2007: Structural and genetic evidence that the Escherichia coli O148O antigen is the precursor of the Shigella dysenteriae type 1 O antigen and identification of a glucosyltransferase gene. Shigella dysenteriae type 1 is the most virulent serotype of Shigella. Enterotoxigenic Escherichia coli O148 is pathogenic and can cause diarrhoea. The following structure was established for the tetrasaccharide repeating unit of the E. coli O148...

Barinova, N.; Zhilina, E.; Bass, I.; Nikiforov, V.; Kulbachinskiy, A., 2008: Lineage-specific amino acid substitutions in region 2 of the RNA polymerase sigma subunit affect the temperature of promoter opening. Highly conserved amino acid residues in region 2 of the RNA polymerase sigma subunit are known to participate in promoter recognition and opening. We demonstrated that nonconserved residues in this region collectively determine lineage-specific di...

Smythe, J.; Yolton, R.L.; Leroy, A.; Achong, R.; Caroline, P.; Van Nurden, M.; Yolton, D., 2001: Use of teleoptometry to evaluate acceptability of rigid gas-permeable contact lens fits. Teleoptometry involves the transmission of digitized optometric information from a remote site for analysis by an expert. This project assessed computer compression of video data showing contact lens fitting relationships and the transmission of t...

Anonymous, 2011: Ascl1-induced neuronal differentiation of P19 cells requires expression of a specific inhibitor protein of cAMP-dependent protein kinase. CAMP-dependent protein kinase (PKA) plays a critical role in nervous system development by modulating sonic hedgehog and bone morphogenetic protein signaling. In the current studies, P19 embryonic carcinoma cells were neuronally differentiated by...

Hara, M.; Mukoyama, J.; Tsuruhara, T.; Ashiwara, Y.; Saito, Y.; Tagaya, I., 1978: Acute gastroenteritis among schoolchildren associated with reovirus-like agent. During early summer 1975 and spring 1976, outbreaks of acute gastroenteritis were reported from primary schools and other institutions in several districts of Japan. Outbreaks occurred in an explosive manner resembling mass food poisoning from a s...