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Plasmodium in the postgenomic era: new insights into the molecular cell biology of malaria parasites


, : Plasmodium in the postgenomic era: new insights into the molecular cell biology of malaria parasites. International Review of Cell and Molecular Biology 266: 85-156

In this review, we bring together some of the approaches toward understanding the cellular and molecular biology of Plasmodium species and their interaction with their host red blood cells. Considerable impetus has come from the development of new methods of molecular genetics and bioinformatics, and it is important to evaluate the wealth of these novel data in the context of basic cell biology. We describe how these approaches are gaining valuable insights into the parasite-host cell interaction, including (1) the multistep process of red blood cell invasion by the merozoite; (2) the mechanisms by which the intracellular parasite feeds on the red blood cell and exports parasite proteins to modify its cytoadherent properties; (3) the modulation of the cell cycle by sensing the environmental tryptophan-related molecules; (4) the mechanism used to survive in a low Ca(2+) concentration inside red blood cells; (5) the activation of signal transduction machinery and the regulation of intracellular calcium; (6) transfection technology; and (7) transcriptional regulation and genome-wide mRNA studies in Plasmodium falciparum.

US$19.90

PMID: 18544493

DOI: 10.1016/S1937-6448(07)66003-1


Other references

Smith, M.J.; Britten, R.J.; Davidson, E.H., 1975: Studies on nucleic acid reassociation kinetics: reactivity of single-stranded tails in DNA-DNA renaturation. The reassociation kinetics of Escherichia coli DNA were measured by S1 nuclease resistance and hydroxyapatite binding. While the reaction assayed by hydroxyapatite displays second order kinetics, the S1 nuclease measurements follow a non-second or...

Curtis, A.C., 2011: Evaluation of the serological test for syphilis. Journal - Michigan State Medical Society 46(7): 811-811

Anonymous, 1974: Control of cooperatives by their followers: An experience in Great Britain. Economie agricole: 28 (11) 24-28

Pipkorn, R.; Boenke, C.; Gehrke, M.; Hoffmann, R., 2002: High-throughput peptide synthesis and peptide purification strategy at the low micromol-scale using the 96-well format. The increasing demand for short- and medium-sized peptides in many fields of biological, medical and pharmaceutical research requires optimized and universally applicable high-throughput synthesis and purification techniques at the low-mumol scale...

Lee R.G., 1979: Long latency electro myography responses to load perturbations in patients with abnormalities of central motor control mechanisms. Acta Neurologica Scandinavica Supplementum 60(73): 20-21

van den Broek, M.D.; Bradshaw, C.M.; Szabadi, E., 1984: The effects of a psychological "stressor" and raised ambient temperature on the pharmacological responsiveness of human eccrine sweat glands: implications for sweat gland hyper-responsiveness in anxiety states. The responsiveness of eccrine sweat glands to local intradermal injections of carbachol was studied in six male healthy volunteers using a plastic paint impression method. A psychological "stressor" (performance of a mental arithmetic ta...

Mannino, M.A.; Catalano, G.; Talamo, S.; Mannino, G.; D.S.lvo, R.; Schimmenti, V.; Lalueza-Fox, C.; Messina, A.; Petruso, D.; Caramelli, D.; Richards, M.P.; Sineo, L., 2013: Origin and diet of the prehistoric hunter-gatherers on the mediterranean island of Favignana (Ègadi Islands, Sicily). Hunter-gatherers living in Europe during the transition from the late Pleistocene to the Holocene intensified food acquisition by broadening the range of resources exploited to include marine taxa. However, little is known on the nature of this di...

Schmidt, J.M.; Richardson, R.L., 1962: Serology of Bacterionema matruchotii. Schmidt, Jean M. (State University of Iowa, Iowa City) and Robert L. Richardson. Serology of Bacterionema matruchotii. J. Bacteriol. 83:584-589. 1962.-Serological relationships of Bacterionema matruchotii were studied by means of the complement-fi...

Goff, D.A.; Gauvreau, K.; Quigley, D.; Lock, J.E.; Jenkins, K.J., 1999: Clinical outcomes after Fontan fenestration closure. Circulation 100(18 SUPPL ): I 99, Nov 2

Guroff, G.; Rhoads, C.A., 1967: Phenylalanine hydroxylase from Pseudomonas species (ATCC 11299a). Purification of the enzyme and activation by various metal ions. Journal of Biological Chemistry 242(16): 3641-3645