+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Polycyclic aromatic hydrocarbons (PAHs) in different indoor dusts and their potential cytotoxicity based on two human cell lines

, : Polycyclic aromatic hydrocarbons (PAHs) in different indoor dusts and their potential cytotoxicity based on two human cell lines. Environment International 36(6): 542-547

In this study, 55 air-conditioner filter dust samples from six different workplaces including commercial office, secondary school, shopping mall, hospital, electronic factory and manufacturing plant in Hong Kong were collected for analyses of PAH concentration and cytotoxicity. Chemical analyses showed that the total PAHs ranged from 1.17 to 25.5 microg/g, with the dust samples from manufacturing plant having the highest concentration. MTT (3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltetrasodium bromide) assay was performed to evaluate the cytotoxicity of organic dust extracts using human hepatocellular liver carcinoma cell line (HepG2) and human skin keratinocyte cell line (KERTr). Each organic dust extract showed marked dose-related response. Dust samples from the manufacturing plant showed the highest cytotoxicity. Curve estimation indicated that power model was fit for explaining the relationship between the total PAH concentration and lethal concentration 50 (LC(50)). In addition, a significant negative correlation was observed between the total PAH concentration and LC(50) both on HepG2 (r=-0.65, p<0.01) and KERTr (r=-0.63, p<0.01) cell lines. Source analyses demonstrated that the PAHs in dust were derived from pyrogenic origins.


PMID: 20452024

DOI: 10.1016/j.envint.2010.04.006

Other references

Santana C.S.; Harrison P.C.; Gonyou H.W., 1992: Use of thermal conducting surfaces in the head region of farrowing crates. Journal of Animal Science 70(SUPPL 1): 169

Staedeli, JH., 1972: Keeping a frog alive and happy. Zoonooz, 454: 4-11

Harkins, K.G.; King, D.S.; Wofford, M.R.; Brown, C.A.; Wyatt, S.B.; Miller Davis, M.E.; Ramsey, L.A.; Jones, D.W., 2000: Screening for dyslipidemia in resident training clinics Is cardiovascular risk management adequate?. American Journal of Hypertension 13(4 Part 2): 101A, April

Timofeev-Resovskii, N.V.; Svirezev, F.M., 1970: Population genetics and optimal processes. Certain similarities between some laws of population genetics and the general principles of the theory of optimized processes are considered, and the relationship between some problems of population genetics and the theory of games is examined. It...

Wahl, A.J.; Combe, E.C.; Polack, M.A.; Martens, L.V., 2002: Effect of water quality on the bonding of resin to moist dentin. To test the effect of different water samples, used for rinsing the dentin, following acid conditioning, on the bond strength of a resin-based composite (RBC) restorative material (Z100), to dentin using a one-bottle dentin adhesive (Single Bond)....

Balzano, A.J.P., 1990: Tree planting in Haiti: agroforestry and rural development in a local context. This study, based on 16 months of fieldwork during 1985/86, seeks to answer why Haitian cultivators are cash-cropping trees as a part of an anthropologically informed AID-funded tree-planting project. Cultivators plant trees in the most fertile ar...

Máslanko, G.; Bogucka-Gordziejko, M.; Rozyło, T.K.; Hutowska-Lukasiewicz, M., 1984: Hemorrhagic cysts. Czasopismo Stomatologiczne 37(4): 235-238

Tasaki, H.; Yamashita, K.; Nakashima, Y.; Kuroiwa, A.; Tulenko, T.N., 1995: Minimal modified low-density lipoprotein induces arterial contraction by inhibition of basal EDRF release. European Heart Journal 16(ABSTR SUPPL ): 231

Hoepfner, R.W.; Sinden, R.R., 1993: Amplified primer extension assay for protein photoproducts provides a sensitive assay for a -6TA -2 -8 Z-DNA torsionally tuned probe Preferential psoralen photobinding to one strand of a B-Z junction. An amplified primer extension assay has been developed for quantitatively mapping the sites of psoralen photoaddition to DNA. This assay was applied to a torsionally tuned Z-DNA-probe that was specifically designed for the primer extension assay....

Anagnostou, T.; Fong, Y.Kit.; Remzi, M.; Dobrovits, M.; Kaisary, A.; Djavan, B., 2006: What's New in Prostate Cancer, Benign Prostatic Hyperplasia, and Minimally Invasive Surgery?: Highlights from the XIXth Congress of the European Association of Urology, March 23-27, 2004, Vienna, Austria. Reviews in Urology 7(1): 18-40