+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Positive regulation of plasmacytoid dendritic cell function via Ly49Q recognition of class I MHC

, : Positive regulation of plasmacytoid dendritic cell function via Ly49Q recognition of class I MHC. Journal of Experimental Medicine 205(13): 3187-3199

Plasmacytoid dendritic cells (pDCs) are an important source of type I interferon (IFN) during initial immune responses to viral infections. In mice, pDCs are uniquely characterized by high-level expression of Ly49Q, a C-type lectin-like receptor specific for class I major histocompatibility complex (MHC) molecules. Despite having a cytoplasmic immunoreceptor tyrosine-based inhibitory motif, Ly49Q was found to enhance pDC function in vitro, as pDC cytokine production in response to the Toll-like receptor (TLR) 9 agonist CpG-oligonucleotide (ODN) could be blocked using soluble monoclonal antibody (mAb) to Ly49Q or H-2K(b). Conversely, CpG-ODN-dependent IFN-alpha production by pDCs was greatly augmented upon receptor cross-linking using immobilized anti-Ly49Q mAb or recombinant H-2K(b) ligand. Accordingly, Ly49Q-deficient pDCs displayed a severely reduced capacity to produce cytokines in response to TLR7 and TLR9 stimulation both in vitro and in vivo. Finally, TLR9-dependent antiviral responses were compromised in Ly49Q-null mice infected with mouse cytomegalovirus. Thus, class I MHC recognition by Ly49Q on pDCs is necessary for optimal activation of innate immune responses in vivo.


PMID: 19075287

DOI: 10.1084/jem.20080718

Other references

Subramaney, U.; Wyatt, G.Elizabeth.; Williams, J.K.; Zhang, M.; Liu, H.Hu.; Chin, D., 2015: Depressive and post-traumatic stress symptoms following termination of pregnancy in South African women: A longitudinal study measuring the effects of chronic burden, crisis support and resilience. Termination of pregnancy (TOP) remains a controversial issue, regardless of legislation. Access to services as well as psychological effects may vary across the world. To better understand the psychological effects of TOP, this study describes the...

Ota, M.; Kuriyama, C.; Sugawara, S.; Kikuchi, A.; Araki, S., 2004: Aortitis syndrome treated with intraaortic stenting. Nihon Naika Gakkai Zasshi. Journal of the Japanese Society of Internal Medicine 92(12): 2409-2411

Ohigashi T.; Hagiwara M., 1989: Partial cystectomy for bladder cancer. We reviewed 27 patients who underwent partial cystectomy in the treatment of primary transitional cell carcinoma of the bladder, and studied histopathological factors affecting clinical course. Intravesical recurrence was seen in 12 patients (44%)...

Halldin, S.; Grip, H.; Jansson, P.E.; Lindgren, A., 1980: Micrometeorology and hydrology of pine forest ecosystems. II. Theory and models. Based on data reported in the preceding abstract.

Young, JO.; Harris, JH., 1973: Another instance of haemoglobin in a flatworm Phaenocora typhlops Vejdovsky 1880. Freshwater Biol, 31: 85-88

Anonymous, 2013: Diagnostik der Lungentuberkulose mit Ziehl-Neelsen-Farbung und Polymerasekettenreaktion. Die sichere Diagnostik unklarer pulmonaler L sionen erfordert meist morphologische Methoden. Hier kommen Tumoren, entz ndliche Prozesse und insbesondere eine Tuberkulose in Betracht. Ziel dieser Untersuchung war der Einsatz etablierter Methoden au...

Lowe, Gordon, D.O., 2003: Virchow's triad revisited: Abnormal flow. Virchow rightly recognised that blood flow plays an important role in thrombosis. The roles of blood flow in haemostasis, and in arterial, intra-cardiac, and venous thrombosis are reviewed. In streamline (laminar) flow, shear stresses are maximal...

Vandenberghe, K.; Van Hecke, P.; Van Leemputte, M.; Gillis, N.; Vanstapel, F.; Hespel, P., 1995: Effect of oral creatine supplementation on muscle phosphocreatine and performance during high-intensity exercise. Pfluegers Archiv European Journal of Physiology 430(4 SUPPL ): R114

Mautino, K.S., 2005: Welfare reform--what does it do?. Journal of Immigrant Health 1(1): 3-7

Pavlov, B.V., 1961: Nineteenth Conference on Problems in Higher Nervous Activity. Zhur Vysshei Nerv Deiaternosti Im I P Pavlova [Transl] 11(4): 139-141