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Posological Considerations of Ocimum sanctum (Tulasi) as per Ayurvedic Science and Pharmaceutical Sciences

, : Posological Considerations of Ocimum sanctum (Tulasi) as per Ayurvedic Science and Pharmaceutical Sciences. Indian Journal of Pharmaceutical Sciences 76(3): 240-245

A study in 2010 reported that administration of 2 g of O. sanctum leaves for 30 days to laboratory male albino rabbits showed adverse effect on sperm count and male hormones. The dose and duration at which this testing was reported was commented upon as being high. It is learnt that basis this publication a few European regulators have imposed restrictions on usage of O. sanctum. Recognizing the need for evaluation, a review has been made of the posological considerations related to decision on dose of a drug in pharmaceuticals (drug development stages) and in Ayurvedic science as part of history of use and current usage. Specifically, we report the dose range as per documented tradition, marketed products containing O. sanctum as an ingredient and current clinical practice. Greater consultation is suggested before deciding the studies on Ayurvedic herbs. Regulatory action of banning use of O. sanctum needs a review and may need to be replaced with an advisory.


PMID: 25035537

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Sørheim, I-Cecilie.; Johannessen, A.; Gulsvik, A.; Bakke, P.S.; Silverman, E.K.; DeMeo, D.L., 2010: Gender differences in COPD: are women more susceptible to smoking effects than men?. The number of female smokers developing chronic obstructive pulmonary disease (COPD) is rapidly increasing, but whether or not there exists a differential susceptibility by gender remains controversial. How smoking behaviour and subsequent lung fu...

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Sia, Calvin C.J., 1966: Leprosy. Current Pediatric Therapy: -1967 702-704

Rosie, D.A.; Shone, G.G., 1969: The analysis of fats containing cyclopropenoid fatty acids. 2. Determination with hydrogen bromide. Methods for estimating total fatty cycloprenoids by reaction with HBr in a benzene medium are described. Contrary to previous indications this reaction proceeds rapidly at room temperature.

Kien, J., 1979: Variability of locust motoneuron responses to sensory stimulation: a possible substrate for motor flexibility. JOURNAL OF COMPARATIVE PHYSIOLOGY 134(1): 55-68

Avise J.C., 1992: Molecular population structure and the biogeographic history of a regional fauna a case history with lessons for conservation biology. Mitochondrial (mt) DNA data on the comparative phylogeographic patterns of 19 species of freshwater, coastal, and marine species in the southeastern U.S.A. are reviewed. Nearly all assayed species exhibit extensive mtDNA polymorphism, although sti...

Lüders, H.O., 1999: Current status and future developments in the treatment of medically intractable epilepsy in adults. Rinsho Shinkeigaku 39(1): 77-77

Janfaza, M.; Martin, M.; Skinner, R., 2012: A preliminary comparison study of two noncrosslinked biologic meshes used in complex ventral hernia repairs. The biologic materials currently available for hernia repairs are costly and there are limited statistics on recurrences and rates of infection in connection with their use in complex cases. We performed a retrospective review and comparison of tw...

Cooper, G.M., 1985: Structure and function of ras and Blym oncogenes. Haematology and Blood Transfusion 29: 273-276