geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Potential benefit of transrectal saturation prostate biopsy as an initial biopsy strategy: decreased likelihood of finding significant cancer on future biopsy


, : Potential benefit of transrectal saturation prostate biopsy as an initial biopsy strategy: decreased likelihood of finding significant cancer on future biopsy. Urology 83(4): 714-718

To identify the ability of transrectal saturation prostate biopsy (SPBx) as the initial diagnostic approach to reduce the likelihood of finding previously unrecognized prostate cancer (PCa) during repeat prostate biopsy. We reviewed PCa detection in 561 men who underwent first repeat SPBx after initial negative biopsy between March 2002 and April 2012. We divided the patients on the basis of the number of cores retrieved on initial biopsy (group 1, initial negative SPBx [n = 81] and group 2, initial negative extended prostate biopsy [n = 480]). The yield of repeat SPBx was compared between the 2 groups. Insignificant PCa and low-risk PCa were defined according to Epstein criteria and D'Amico risk criteria, respectively. PCa detection on first repeat SPBx was 43.1% lower in group 1 (19.8% vs 34.8%; P = .008). Moreover, lower rate of significant PCa (31.3% vs 74.3%; P <.001) and intermediate- and/or high-risk PCa (25.0% vs 50.9%; P = .048) in group 1. Multivariate analysis confirmed that initial negative SPBx decreased PCa detection on first repeat SPBx (odds ratio = 0.41, 95% confidence interval 0.22-0.78). Men whose initial biopsy was per transrectal saturation technique were less likely to have cancer identified during repeat biopsy. Furthermore, PCa diagnosed after negative initial SPBx was much more likely to be clinically insignificant. These findings suggest that SPBx may be less likely to miss clinically significant cancer during initial prostate biopsy. If confirmed in other studies, this suggests that initial biopsy by saturation technique may eliminate the need for most men to undergo repeat biopsy.

US$19.90

PMID: 24680442

DOI: 10.1016/j.urology.2013.12.029


Other references

Chang, Y-Ping.; Chiang, H.; Shih, K-Shang.; Ma, H-Li.; Lin, L-Chyr.; Hsu, W-Li.; Huang, Y-Cheng.; Wang, H-Kuo., 2016: Effects of Therapeutic Physical Agents on Achilles Tendon Microcirculation. Controlled laboratory study. To measure Achilles tendon microcirculation (total hemoglobin [THb] and oxygen saturation [StO2]) before and after the application of a physical agent in asymptomatic participants, and to compare differences between ap...

Corby, H.D.L., 1974: Systematic implications of nodulation among Rhodesian legumes. Lists 539 native species of Leguminosae, noting the presence or absence of root nodules and also the habit of each species. The list includes new positive records of nodulation in many genera and species. The number of species without nodules in e...

Meena, B.; Jeyalakshmi, V., 2006: Integrated management of basal stem rot disease of coconut. Journal of Plantation Crops 34(3): 517-518

Low, A., 1982: A comparative advantage theory of the subsistence farm-household: applications to Swazi farming. The paper suggests that the question of comparative advantage in on-farm and off-farm production is particularly relevant to traditional farming in southern Africa. A feature of farming in many countries of the region is the prevalence of the part...

Zhou, Z.J.; Vaillancourt, F.; Liang, P.; Richard, C.; Menard, H.A., 2000: Propylthiouracil-induced vasculitis A multi-antigen-driven autoantibody response. Clinical & Experimental Immunology 120(Suppl 1): 62, May

Regan, W.A., 1982: Bedfalls and nursing liability: legal factors. Regan Report on Nursing Law 22(11): 1-1

Schockaert, Er, 1971: Turbellaria from Somalia. 1. Kalyptorhynchia (Part 1). Monitore zool(N.S.): 101-122, Suppl.

Harris, R.I.; Wallace, A.L.; Harper, G.D.; Goldberg, J.A.; Sonnabend, D.H.; Walsh, W.R., 2000: Structural properties of the intact and the reconstructed coracoclavicular ligament complex. Numerous procedures have been described for the operative management of acromioclavicular joint injuries, but surprisingly little information is available on the ultimate mechanical behavior of the native coracoclavicular ligament complex or on th...

Dorfman, W., 1970: A psychiatrist looks at allergy. Annals of Allergy 28(7): 321-323

Serati, M.; Leone Roberti Maggiore, U.; Sorice, P.; Cantaluppi, S.; Agrò, E.Finazzi.; Ghezzi, F., 2016: Is mirabegron equally as effective when used as first- or second-line therapy in women with overactive bladder?. No previous studies have investigated the efficacy of mirabegron 50 mg as the first-line therapy in OAB patients. Hence, the primary objective of this study was to evaluate the efficacy of mirabegron in treatment-naive patients in comparison with...