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Potential coeliac disease in Type 1 diabetes mellitus: does a positive antibody lead to increased complications?


, : Potential coeliac disease in Type 1 diabetes mellitus: does a positive antibody lead to increased complications?. Nutrition, Metabolism, and Cardiovascular Diseases 24(4): 378-383

Coeliac disease (CD) is more common in people with Type 1 diabetes and is associated with poorer glycaemic control, lipid profiles, nephropathy and retinopathy. Potential CD (positive serology but normal duodenal biopsy) is associated with neuropathy but patients with coexisting Type 1 diabetes were excluded. The aim was to determine whether potential CD is associated with increased microvascular complications in patients with Type 1 diabetes. Four groups were recruited; 1) patients with Type 1 diabetes and potential CD, 2) patients with Type 1 diabetes and newly identified CD, 3) patients with Type 1 diabetes alone and 4) patients with CD alone. Glycaemic control, quality of life, lipid profile and microvascular complication rates were examined. As many as 76 individuals were included in the study: 22 in group 1, 14 in group 2, 24 in group 3 and 16 in group 4. There were no differences in age, gender, BMI and diabetes duration between the groups. Patients in group 1 had significantly lower total cholesterol compared to group 3 (p = 0.003) but higher than group 2 (p = 0.027). There were no significant differences in HbA1c, HDL cholesterol, cholesterol:HDL ratio, creatinine, quality of life scores or prevalence of neuropathy between individuals in group 1 and the other groups. This is the first study to assess the effects of potential CD in patients with Type 1 diabetes. It appears that an enteropathy is required as well as antibody positivity in order to increase the risk of diabetes related complications. This pilot data requires further longitudinal validation.

US$19.90

PMID: 24393392

DOI: 10.1016/j.numecd.2013.09.005


Other references

Trivinho Strixino, S.; Correia, L.C.S.; Sonoda, K., 2000: Phytophilous Chironomidae (Diptera) and other macroinvertebrates in the ox-bow Infernao Lake (Jatai Ecological Station, Luiz Antonio, SP, Brazil). Infernao Lake, in the Jatai Ecological Station in Luiz Antonio Municipal district (Sao Paulo State, Brazil), is a typical ox-bow lake of the Mogi-Guacu River; its main feature is its great quantity of aquatic macrophytes. This study, conducted in...

Kawanabe, H., 1967: Defication ratio of a young erucian carp. Carassius camssius, in relation to its ingestion rate. Memoirs of the College of Science Kyoto University, 33B 157-162

Wright E.P., 1985: Groundwater in the Third World. IAHS-AISH Publication 154(1): 53-64

Hageman, G.J.; Verhagen, H.; Kleinjans, J.C., 1988: Butylated hydroxyanisole, butylated hydroxytoluene and tert.-butylhydroquinone are not mutagenic in the Salmonella/microsome assay using new tester strains. The phenolic antioxidants butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT) and tert.-butylhydroquinone (TBHQ) were reassessed for mutagenic activity using the recently developed Salmonella tester strains TA97, TA102 and TA104, and in...

Miasnicov, I.T.dorascu, R.D.mitrescu, I.S.teanu, M.L.zinschi, A., 1980: Activity of some enzymes in the fetal fluids of sow. Lucrarile Simpozionului Reproductia si Patologia Reproductiei in Cresterea Intensiva a Animalelor Bucuresti 8-9 decembrie 1978 colectiv de redactie V Popovici et al: 7

Dukes, I.D.; Vaughan Williams, E.M., 1984: Effects of selective a1-, a2-, b1- and b2-adrenoceptor stimulation on potentials and contractions in the rabbit heart. The Journal of Physiology 355: 3-46

Riddell, Be, 1993: Spatial organization of Pacific salmon: what to conserve?. NATO ASI series Series A Life sciences48(248): 23-41

Arvestad, L.; Berglund, A-Charlotte.; Lagergren, J.; Sennblad, B., 2003: Bayesian gene/species tree reconciliation and orthology analysis using MCMC. Comparative genomics in general and orthology analysis in particular are becoming increasingly important parts of gene function prediction. Previously, orthology analysis and reconciliation has been performed only with respect to the parsimony mod...

Razmaev I.I., 1975: Relation between plant transpiration and metabolism. Uzbekskii Biologicheskii Zhurnal 19(1): 18-21

Ciani, A.; Catapano, B., 1969: Use of the electric knife in dental surgery. Dental Cadmos 37(1): 65-70