geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Potential triazole derivatives having significant antiepileptic effect- A Review


, : Potential triazole derivatives having significant antiepileptic effect- A Review. Mini Reviews in Medicinal Chemistry: -

Triazole is a five membered heterocyclic moiety of two carbon and three nitrogen atom, triazole are present in two isomeric forms, 1,2,4-triazole and 1,2,3-triazole. Alprazolam, Triazolam and Midazolam are established drugs used in epilepsy which have triazole moiety. Epilepsy is the most frequent neurological disorder characterized by excessive temporary neuronal discharge. The overall prevalence of the disease is 1% of the population and up to 50 million people worldwide. The literature shows that different substitution on triazole moiety exhibit potent antiepileptic activity and less/no neurotoxicity. The maximal electroshock seziures test is most widely used in- vivo models among the various screening models of epilepsy. The present article focused on the previous researches on triazole, which include synthesis, spectral characterization and antiepileptic activity of the synthesized triazole derivatives, and we also go for the development of structure activity relationship of the earlier synthesized triazole derivatives with reference to their pharmacological effect.

US$29.90

PMID: 22876955


Other references

Bandemer, S.L.; Schaible, P.J., 1942: Mineral partition during intestinal digestion of normal- and high-mineral rations by chicks. Preliminary expts. in vitro showed that an excess of such mineral supplements as oyster shell and bone meal removed Ca partially, and P more completely, from soln. A method was developed to study these effects of excess mineral upon absorption in...

Suzuki, T.; Hoshino, T.; Matsushika, A., 2014: Draft Genome Sequence of Kluyveromyces marxianus Strain DMB1, Isolated from Sugarcane Bagasse Hydrolysate. We determined the genome sequence of a thermotolerant yeast, Kluyveromyces marxianus strain DMB1, isolated from sugarcane bagasse hydrolysate, and the sequence provides further insights into the genomic differences between this strain and other re...

Abasse, M.Leonor.Ferreira.; de Oliveira, R.Coimbra.; Silva, T.Campos.; de Souza, E.Ramos., 2009: Epidemiological analysis of morbidity and mortality from suicide among adolescents in Minas Gerais, Brazil. This study is a descriptive epidemiological analysis of morbidity and mortality from suicide in people aged 10 to 19 years living in the state of Minas Gerais. The source of the mortality data were the data available in the Mortality Information S...

Archer, D.P., 2010: Intracranial pressure and the anaesthetist. Canadian Journal of Anaesthesia 34 Suppl 1: S51-S54

Gavelová, M.; Badonic, T.; Mitro, A., 1983: Altered axons and axon terminals in the nucleus gracilis of the dog. Altered axons and axon terminals in the nucleus gracilis o the dogs were followed by means of electron microscopy. The axon terminals with characteristic ultrastructure were accompanied by synapses with altered presynaptic part. The changes of the...

Lalitha, C.M.; Alwar, V.S., 1960: Parasites of domestic ducks in Madras. Twenty-five ducks were examined for ecto- and endoparasites. A complete list of the parasites recovered is given in this paper.

Parr, L.W.; Cald Well, E.L., 1933: Comparison by direct inoculation of brilliant green bile two percent and lactose broths including consideration of the parallel planting method of water analysis. Studies on brilliant green bile broth used in conjunction with lactose broth in analysis of water samples by the direct method have substantiated most of the claims made for this medium. The outstanding exception is the well-nigh complete inhibiti...

Cataldo, F.; Bellia, L.; Violante, M.; Albeggiani, A., 1983: Transient paralysis of the vagus and the hypoglossal nerves in pertussis in a 2 1/2-month-old infant. La Pediatria 91(4): 429-434

Shier, R.V., 1918: Ruptured ectopic-blood transfusion and pulmonary embolism. Canadian Medical Association Journal 8(5): 427-428

Hepp, Albert, 1927: Notes on the Macrolepidoptera fauna of Frankfurt a/M. Lepidop Terologische Rundschau22-23: 175-176, 177-179, 185-189